ArticleThe Journal of international medical research2025
Preparation and properties of polyvinyl alcohol/calcium phosphate composite bone cement.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
BackgroundThe inherent brittleness of calcium phosphate cement has limited its clinical application. Polyvinyl alcohol fibers have been demonstrated to enhance the tensile toughness of concrete matrices. However, only a few international studies have investigated the modification of calcium phosphate cement using polyvinyl alcohol fibers. These studies have predominantly focused on the macroscopic and microscopic mechanical properties, often neglecting comprehensive evaluations of the composites' osteoconductivity, degradation rate, and osteogenic properties.ObjectiveTo evaluate the cellular biocompatibility, bending strength, elastic modulus, and fracture toughness of polyvinyl alcohol/calcium phosphate cement composites, as well as to assess their degradability and osteoconductivity, providing a theoretical basis for their potential clinical application.MethodPolyvinyl alcohol/calcium phosphate cement composite cement was prepared by incorporating polyvinyl alcohol fibers into the calcium phosphate cement solid phase. The degradability of the composite material was assessed via in vitro immersion experiments. Biocompatibility was evaluated by observing cell morphology and growth, using the cell counting kit-8 for assessing the cell viability and performing live/dead fluorescent staining. The impact of the composite on cellular alkaline phosphatase activity was determined using alkaline phosphatase assays. Finally, the composite material's bending strength, elastic modulus, and fracture toughness were measured through three-point bending tests.
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