ReviewProbiotics and antimicrobial proteins2026
Probiotics as a Therapeutic Strategy for Obesity: New Thoughts on the Stress Response Mechanisms of Probiotics In Vitro and In Vivo.
Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Probiotics are widely used in the prevention and care of obesity. Despite a large number of studies focusing on exploring benefits, probiotics inevitably encountered unexpected stress and challenges in vitro or in vivo during the practical application, which could substantially influence their viability and biological functions. This study summarized the literature that investigated the keywords of probiotics, obesity, and stress. The most reported probiotics genera related to obesity treatments (i.e., Lactobacillus, Bifidobacterium, yeast, and certain potential next-generation beneficial microorganisms), the key stress factors they encounter (i.e., gastric, cholate, organic acid, and other osmotic pressure stress during in vitro fermentation and in vivo application), and potential mechanisms for stress tolerance of certain probiotics were summarized. The main approaches for probiotics to resist stress are regulating the expression of some critical genes, increasing intracellular ATP, maintaining cell membrane function, and enhancing key metabolic pathways. We made recommendations for further research on the stress resistance mechanism of probiotics. The findings provide insights into the mechanisms of stress tolerance of probiotics and for screening of probiotics and development of novel probiotic foods with enhanced efficacy to combat obesity.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.