ArticleNature structural & molecular biology2026
TMEM170 proteins are lipid scramblases associated with bridge-type lipid transporters BLTP1/Csf1.
Article in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Lipid flip-flop in biological membranes: through the lens of TMEM16F.Physiological reviews · 2026Review
- Article
- Correlation Analysis ofGenes · 2026Article
- The molecular mechanism of lipid uptake by membrane-anchored bridge-like lipid transfer proteins.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Bulk lipid transport between organelles has been proposed to involve the partnership between bridge-like lipid transfer proteins (BLTPs) and membrane-embedded lipid scramblases. However, for almost all BLTPs, such physical association has not been fully described and, in most cases, the identity of the scramblases is unknown. Here we identify TMEM170-family proteins as endoplasmic reticulum lipid scramblases that physically interact with BLTP1/Csf1 proteins and we provide a revised model detailing the structure of this protein complex in Caenorhabditis elegans. This finding opens avenues to understand the mechanistic basis of lipid transport at membrane contact sites.
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