ReviewDrug delivery and translational research2026
Ectoine as a multifunctional molecule: biotechnological production and pharmaceutical applications.
Review in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Unveiling hidden microbial diversity in Mars 2020 mission assembly cleanrooms with molecular insights into the persistence and perseverance of novel species defying metagenome sequencing.Microbiology spectrum · 2026Article
- Biosynthesis and import of the cytoprotective extremolytes ectoine and hydroxyectoine in the phylumFrontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional topical therapies can have considerable side effects, leading to the research for natural and biocompatible alternatives. Ectoine, a natural osmolyte produced by extremophilic microorganisms, possesses an extraordinary ability to bind water molecules and stabilize membranes, with powerful moisturizing and anti-inflammatory properties, which makes it a multifunctional and valuable molecule for topical applications. Pre-clinical and clinical data confirm that ectoine-based creams increase skin moisture, improve the skin's barrier function, and reduce inflammation, effectively alleviating the symptoms of atopic dermatitis. In addition, ectoine can be used in nasal sprays, providing substantial relief from the symptoms of rhinosinusitis, such as nasal congestion and irritation of the mucous membranes, without the adverse effects associated with the usual decongestants. In ophthalmic formulations, ectoine-containing eye drops moisturize, stabilize the tear film, and relieve irritation and itching, making them a viable option for the ocular symptoms of allergic conjunctivitis and the long-term treatment of dry eye disease. Therefore, ectoine is crucial in developing treatments that improve patients' quality of life by offering a safer alternative to conventional therapies.Briefly, this review aims to explore the topical applications, characteristics, and mechanisms of action of ectoine, focusing on its efficacy and safety in the treatment of atopic dermatitis, rhinosinusitis, rhinitis sicca, dry eye disease, and allergic conjunctivitis. Moreover, biotechnological methods for producing ectoine are outlined, highlighting advances in microbial synthesis and process optimization for more sustainable technology, as well as showing ectoine-containing products and their position on the market.
Indexed as
Identifiers
41299111What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.