ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Opioid and sedative use in extremely preterm infants receiving mechanical ventilation.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Fentanyl Exposure Is Associated with Adverse Respiratory Outcomes in Ventilated Preterm Neonates: A Retrospective Matched Cohort Study.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveQuantify opioid and sedative medication exposures in preterm infants receiving mechanical ventilation. STUDY
designCohort study of infants <28 weeks' gestation receiving any mechanical ventilation in the first 28 postnatal days. We examined exposure to morphine, fentanyl, midazolam, and lorazepam. We used logistic regression to examine the association between daily respiratory support and probability of medication administration.
resultsOf 36,067 infants, 15,025 (42%) received one or more medications. There was a decrease in exposure to fentanyl and benzodiazepines from 2012 to 2020. Major morbidities were lower in unexposed infants. The odds of receiving target medications were more than twice as high on high frequency mechanical ventilation days compared to conventional mechanical ventilation days (unadjusted odds ratio 2.47, 95% CI 2.36-2.59).
conclusionIn preterm infants receiving mechanical ventilation, the use of opioids or sedatives was common and high frequency ventilation was associated with higher exposure to medications.
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