ArticleJournal of perinatology : official journal of the California Perinatal Association2025
The nucleated red blood cell count at birth, the volume of red cell transfusions received, and the risk of developing retinopathy of prematurity.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Cord blood red cell concentrates for preterm neonate transfusion: Insights from the multicenter BORN trial.Transfusion · 2026Article
- Designing and implementing a clinical decision support tool to improve compliance with NICU transfusions.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- The risk of developing severe bronchopulmonary dysplasia: evaluating associations with the nucleated red blood cell count at birth and volume of transfusions received.Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPrevious studies described an association between the NRBC count at birth and risk of developing retinopathy of prematurity (ROP). Other studies correlated red blood cell (RBC) transfusions with ROP. We are aware of no studies that examined both NRBC count and RBC transfusions, in the same cohort, on ROP risk. STUDY
designWe retrospectively analyzed all infants in the Intermountain Health NICUs during the past four years who were born <32 weeks had a NRBC count at birth and had ROP examinations.
resultsRecords of 386 infants demonstrated that both factors are associated with ROP. For every 1000/µL increase in NRBC, severe (grade ≥3) ROP increased by 6.8% (95% CI, 3.0-10.0%). RBC transfusions were associated with ROP incidence and severity (p = 0.001). However, neither factor alone was either necessary or sufficient for ROP.
conclusionThe NRBC count at birth and the volume of RBC transfusions both influence ROP severity.
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Registered trials
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