ArticleNature aging2026
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations.
Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Organ-Specific Proteomic Aging Clocks Reveal Complexities Underlying the Healthy Drinking Paradox.Aging cell · 2026Review
- Metabolic exhaustion and immune ageing in rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- Aging in Spaceflight, Oxidative Stress, and Microbiome Dysbiosis: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Proteomic organ-specific signatures, ageing traits, disease risks and genetic architecture in an East Asian population.EBioMedicine · 2026Article
- Plasma proteomics framework predicts metabolic dysfunction-associated steatotic liver disease up to 16 years before onset.Nature aging · 2026Article
- Accelerated Biological Aging, Neurodegenerative Disease, and Mortality in Cardiovascular Disease Patients: Mediation and Modification Analysis.CNS neuroscience & therapeutics · 2026Article
- Liver- and Immune-Enriched Molecular Signatures Associated With Mortality in Older Adults.Aging cell · 2026Article
- Immune responses in aging adults.The Journal of clinical investigation · 2026Review
- Hierarchical organ aging signatures from routine abdominal CT add incremental disease risk stratification beyond blood biomarkers.medRxiv : the preprint server for health sciences · 2026Article
- A Multimodal Framework for Organ- and Cell-Resolved Biological Aging and Longevity Intervention Discovery.medRxiv : the preprint server for health sciences · 2026Article
- Beyond disease treatment and prevention: From geroscience and molecular hallmarks to gerotherapeutics and precision geromedicine.Journal of the Chinese Medical Association : JCMA · 2026Review
- From whole-body to organ-specific biological age clocks.Nature aging · 2026Review
- The BHARAT study: a multi-modal, multi-omics investigation of aging signatures in the Indian population.Aging · 2026Observational
- Plasma Proteomic Profiling of Young and Older Adults Identifies Candidate Biomarkers of Biological Aging at the Intersection of Age and Disease.Aging cell · 2026Article
- Health Galaxy: A Multi-organ Trajectory-Computing Framework in Type 2 Diabetes.Research (Washington, D.C.) · 2026Article
- Brain Age as a Biomarker in Alzheimer's Disease: Narrative Perspectives on Imaging, Biomarkers, Machine Learning, and Intervention Potential.Brain sciences · 2025Review
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
Aging and age-related diseases share convergent pathways at the proteome level. Here, using plasma proteomics and machine learning, we developed organismal and ten organ-specific aging clocks in the UK Biobank (n = 43,616) and validated their high accuracy in cohorts from China (n = 3,977) and the USA (n = 800; cross-cohort r = 0.98 and 0.93). Accelerated organ aging predicted disease onset, progression and mortality beyond clinical and genetic risk factors, with brain aging being most strongly linked to mortality. Organ aging reflected both genetic and environmental determinants: brain aging was associated with lifestyle, the GABBR1 and ECM1 genes, and brain structure. Distinct organ-specific pathogenic pathways were identified, with the brain and artery clocks linking synaptic loss, vascular dysfunction and glial activation to cognitive decline and dementia. The brain aging clock further stratified Alzheimer's disease risk across APOE haplotypes, and a super-youthful brain appears to confer resilience to APOE4. Together, proteomic organ aging clocks provide a biologically interpretable framework for tracking aging and disease risk across diverse populations.
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