Evidence map›Paper›PMID 41299057›Full record

ArticleCommunications biology2025

Unraveling the mesoscale resting-state functional connectivity of ocular dominance columns in humans using high-resolution functional MRI.

Marianna Elisa Schmidt, Iman Aganj, Jason Stockmann, Berkin Bilgic, Yulin Chang, William Scott Hoge, Evgeniya Kirilina, Nikolaus Weiskopf, Shahin Nasr

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Marianna Elisa Schmidt *Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID http://orcid.org/0009-0007-0377-6815
Iman Aganj *Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4673-1293
Jason StockmannAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
Berkin BilgicAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
Yulin ChangSiemens Medical Solutions USA Inc., Malvern, PA, USA.
William Scott HogeImaginostics Inc., Orlando, FL, USA.
Evgeniya KirilinaDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID http://orcid.org/0000-0003-1304-4363
Nikolaus WeiskopfDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID http://orcid.org/0000-0001-5239-1881
Shahin NasrAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA. shahin.nasr@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-7546-9976

Funding

Applications of high resolution fMRI in ultra-high field (7T) in revealing developmental disorders underlying amblyopiaR01EY030434 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI Shahin Nasr · 2020 to 2026
$3.8M
Eye Movement Rehabilitation in Low Vision PatientsR01EY029713 · NEI · NORTHEASTERN UNIVERSITY · PI BEX, PETER JOHN · 2019 to 2023
$1.9M
Connectomic Biomarkers of Preclinical Alzheimer's Disease within Multi-Synaptic PathwaysRF1AG068261 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI AGANJ, IMAN · 2021 to 2021
$1.8M
Connectomic Biomarkers of Preclinical Alzheimer's Disease within Multi-Synaptic PathwaysR01AG068261 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Iman Aganj · 2024 to 2026
$1.2M
7T Translational MRI SystemS10RR019371 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2007 to 2007
$500k
Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01ED2210Deutsche Forschungsgemeinschaft (German Research Foundation) KI 1337/2-2Deutsche Forschungsgemeinschaft (German Research Foundation) WE 5046/4-2NCRR NIH HHS S10 RR019371NEI NIH HHS R01 EY029713NEI NIH HHS R01 EY030434NIA NIH HHS R01 AG068261NIA NIH HHS RF1 AG068261U.S. Department of Health & Human Services | National Institutes of Health (NIH) S10RR019371U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY029713U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY030434U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) RF1AG068261
6 · The paper itself

Abstract

Despite their importance for visual perception, functional connectivity between ocular dominance columns in human primary visual cortex remains largely unknown. Using high-resolution functional MRI, we localize ocular dominance columns and assess their resting-state functional connectivity in 12 human adults. Consistent with anatomical studies in animals, we find stronger connectivity in middle compared to deep and superficial cortical depths and selectively stronger connectivity between columns with alike compared to unalike ocular polarity. Beyond what was known from animal models, and consistent with human perceptual biases, intra- and interhemispheric connectivity is stronger in peripheral (compared to central) and in dorsal (compared to ventral) subregions. Lastly, connectivity patterns correlate with ocular dominance column maps, suggesting that they can be predicted from connectivity patterns within primary visual cortex. These results highlight the heterogeneity in functional connectivity between ocular dominance columns across cortical depths and visual field representations, underscoring their likely association with perceptual features.

Indexed as

Dominance, OcularMagnetic Resonance ImagingPrimary Visual CortexVisual CortexAdultBrain MappingFemaleHumansMaleRestVisual PerceptionYoung Adult

Identifiers

PMID41299057
PMCPMC12658184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.