Evidence map›Paper›PMID 41299018›Full record

ArticleCognitive, affective & behavioral neuroscience2026

Prefrontal and ventral striatal neural correlates of reversal learning in anorexia nervosa and bulimia nervosa.

Matthew F Murray, Brianne N Richson, Glen Forester, Neil P Jones, Elizabeth N Dougherty, Angeline R Bottera, Lisa M Anderson, Lauren M Schaefer, Erika E Forbes, Jennifer E Wildes

Abstract read
In one paragraph

Article in Cognitive, affective & behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew F MurrayDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave., Chicago, IL, MC307760637, USA.
Brianne N RichsonCenter for Biobehavioral Research, Sanford Research, Fargo, ND, USA.
Glen ForesterCenter for Biobehavioral Research, Sanford Research, Fargo, ND, USA.
Neil P JonesDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Elizabeth N DoughertyDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave., Chicago, IL, MC307760637, USA.
Angeline R BotteraLife Span Institute, University of Kansas, Lawrence, KS, USA.
Lisa M AndersonDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Lauren M SchaeferCenter for Biobehavioral Research, Sanford Research, Fargo, ND, USA.
Erika E ForbesDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jennifer E WildesDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S Maryland Ave., Chicago, IL, MC307760637, USA. jwildes@uchicago.edu.

Funding

The Neurocognitive Reward Learning Mechanisms of Binge EatingP20GM134969 · NIGMS · SANFORD RESEARCH NORTH · PI CROSBY, ROSS D · 2021 to 2025
$11.5M
Regional Postdoctoral Training Grant in Eating Disorders ResearchT32MH082761 · NIMH · UNIVERSITY OF MINNESOTA · PI CAROL B. PETERSON · 2009 to 2026
$6.2M
Cognitive Inflexibility and Phenotypic Heterogeneity in Anorexia NervosaR01MH103230 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORBES, ERIKA E, WILDES, JENNIFER E · 2014 to 2018
$2.4M
Neural Bases of Disgust Conditioning in Anorexia NervosaK23MH123910 · NIMH · UNIVERSITY OF MINNESOTA · PI ANDERSON, LISA M · 2020 to 2024
$821k
NIGMS NIH HHS P20 GM134969NIGMS NIH HHS P20GM134969NIMH NIH HHS K23 MH123910NIMH NIH HHS K23MH123910NIMH NIH HHS R01 MH103230NIMH NIH HHS R01MH103230NIMH NIH HHS T32 MH082761NIMH NIH HHS T32MH082761
6 · The paper itself

Abstract

Difficulty with reversal learning (RL)-appropriately shifting behavior following outcome contingency changes-may represent a shared or distinct mechanism across eating disorder (ED) diagnoses. We tested whether RL-related neural correlates differ among adults without and with EDs (anorexia nervosa, restricting subtype [AN-R], AN binge-eating/purging subtype [AN-BP], and bulimia nervosa [BN]) and whether these correlates correspond to ED-symptom severity and frequency. We hypothesized that individuals with EDs would demonstrate differential neural activation during RL relative to individuals without, that activation would differentiate AN-BP and BN versus AN-R, and that activation would predict ED-severity metrics. Medically stable participants with AN-R (n = 22), AN-BP (n = 20), and BN (n = 29) comprised the ED group (N = 71), contrasted with non-ED controls (N = 27). Participants (91% female; M

Indexed as

Anorexia NervosaBulimia NervosaPrefrontal CortexReversal LearningVentral StriatumAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleYoung AdultAnorexia nervosaBulimia nervosaFunctional magnetic resonance imagingNeuroimagingReversal learning

Identifiers

PMID41299018
PMCPMC12685067

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.