Evidence map›Paper›PMID 41298992›Full record

ArticleAAPS PharmSciTech2025

Rheological Properties and Process Temperature Prediction for the Hot Melt Extrusion of Artesunate with Soluplus®/Span®20.

Fabio Moyses Lins Dantas, Maria Helena Miguez da Rocha-Leão, Daniel Lins de Sales, André Luís Marcomini, Cesar Augusto Gonçalves Beatrice, Carlos Henrique Scuracchio, Pedro Henrique da Rocha Franco, Alessandra Lifsitch Viçosa

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Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fabio Moyses Lins DantasLaboratory of Powder Technology, Instituto Nacional de Tecnologia, 82 Venezuela Av., ZIP, Rio de Janeiro, RJ, 20081-312, Brazil. fabio.dantas@int.gov.br.ORCID http://orcid.org/0000-0002-2233-818X
Maria Helena Miguez da Rocha-LeãoGraduate Program in Technology of Chemical and Biochemical Processes, School of Chemistry, Federal University of Rio de Janeiro, 149 Athos da Silveira Ramos Av., ZIP , Rio de Janeiro, RJ, 21941-909, Brazil.ORCID http://orcid.org/0000-0003-2292-4565
Daniel Lins de SalesGraduate Program in Technology of Chemical and Biochemical Processes, School of Chemistry, Federal University of Rio de Janeiro, 149 Athos da Silveira Ramos Av., ZIP , Rio de Janeiro, RJ, 21941-909, Brazil.ORCID http://orcid.org/0009-0008-5645-6417
André Luís MarcominiDepartment of Materials Engineering, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, Washington Luis Highway, Km 235, ZIP , São Carlos, SP, 13565-905, Brazil.ORCID http://orcid.org/0000-0002-8634-0502
Cesar Augusto Gonçalves BeatriceDepartment of Materials Engineering, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, Washington Luis Highway, Km 235, ZIP , São Carlos, SP, 13565-905, Brazil.ORCID http://orcid.org/0000-0003-3871-6883
Carlos Henrique ScuracchioDepartment of Materials Engineering, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, Washington Luis Highway, Km 235, ZIP , São Carlos, SP, 13565-905, Brazil.ORCID http://orcid.org/0000-0002-7723-0213
Pedro Henrique da Rocha FrancoLaboratory of Powder Technology, Instituto Nacional de Tecnologia, 82 Venezuela Av., ZIP, Rio de Janeiro, RJ, 20081-312, Brazil.ORCID http://orcid.org/0009-0001-0880-2839
Alessandra Lifsitch ViçosaFarManguinhos, Oswaldo Cruz Foundation, 100 Sizenando Nabuco St., ZIP , Rio de Janeiro, RJ, 21041-250, Brazil.ORCID http://orcid.org/0000-0001-8511-0003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Active Pharmaceutical Ingredients (API) are highly sensitive molecules and generally have low water solubility and must have their biological performance preserved and enhanced by any process. Hot-melt Extrusion (HME) is one of the preferred methods of preparing Amorphous Solid Dispersions (ASD) for poorly soluble APIs. For HME, the Temperature Profile of Extrusion (TPE) is fundamental to predicting the processability of the mixture among API, polymer, and other ingredients. Dynamic rheological studies can determine the initial TPE from the Soft Point of Mixture (SPM) and the Initial Fusion Plato Temperature (IFPT) by the method of Talmadge-Fitch. Using this approach, the work sought the best extrusion conditions to make blends of Artesunate (AS), Soluplus

Indexed as

ArtemisininsArtesunateHot Melt Extrusion TechnologyPolyethylene GlycolsPolyvinylsCalorimetry, Differential ScanningChemistry, PharmaceuticalDrug CompoundingHot TemperatureMicroscopy, Electron, ScanningRheologySolubilityTemperatureThermogravimetryX-Ray DiffractionArtemisininsArtesunatePolyethylene Glycolspolyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymerPolyvinylsamorphous solid dispersionartesunatehot melt extrusionrheologysoluplus®span®20

Identifiers

PMID41298992

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.