Evidence map›Paper›PMID 41298983›Full record

ArticlePharmaceutical research2025

Comparative Formulation and Physicochemical Evaluation of Orodispersible Films Fabricated via Pneumatic and Syringe-Based 3D Printing.

Ishwor Poudel, Nur Mita, James Scherer, Manjusha Annaji, Xuejia Kang, Oladiran Fasina, Amit K Tiwari, R Jayachandra Babu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ishwor PoudelDepartment of Drug Discovery and Development, Auburn University, Auburn, AL, 36830, USA.
Nur MitaDepartment of Drug Discovery and Development, Auburn University, Auburn, AL, 36830, USA.
James SchererDepartment of Biochemistry, Auburn University, Auburn, AL, 36830, USA.
Manjusha AnnajiDepartment of Drug Discovery and Development, Auburn University, Auburn, AL, 36830, USA.
Xuejia KangDepartment of Drug Discovery and Development, Auburn University, Auburn, AL, 36830, USA.
Oladiran FasinaDepartment of Biosystems Engineering, Auburn University, Auburn, AL, 36830, USA.
Amit K TiwariCollege of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
R Jayachandra BabuDepartment of Drug Discovery and Development, Auburn University, Auburn, AL, 36830, USA. ramapjb@auburn.edu.ORCID http://orcid.org/0000-0003-0337-2291

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOrodispersible films (ODF) blend the dose accuracy of solid dosage forms and the ease of administration of liquid dosage forms, hence offer many advantages. This study investigated the feasibility of two extrusion-based 3D printing techniques (pneumatic and syringe) to fabricate ODFs in a benchtop setting.

methodsWe fabricated fast-dissolving ODFs using pneumatic and syringe print heads and compared the variations in the process parameters, ease of fabrication, and characterized the properties of the final dosage forms. The variation in the printing parameters, drying time, drying temperature, and needle/nozzle types on the reproducibility and uniformity of the ODFs prepared from, these two printheads were studied. Feed materials for extrusion were selected based on rheological properties, printability, and reproducibility. An optimized ODF formulation composition was kept common and utilized for comparison.

resultsThe ODFs from pneumatic and syringe-based extrusion printheads consistently created bulk batches with little to no significant variation. Syringe-based extrusion showed high precision with identical dimensions, whereas pneumatic extrusion showed quick fabrication. The ODFs produced by both methods were highly reproducible and showed excellent film properties such as mechanical strength, disintegration, and dissolution. The ODFs showed adequate mechanical strength (>0.72 N/mm

conclusionBoth pneumatic and syringe-based 3D printing technologies are deemed to be potentially viable alternatives for the fabrication of personalized dosage forms such as ODFs in pharmacy and clinical settings.

Indexed as

Drug CompoundingPrinting, Three-DimensionalAdministration, OralChemistry, PharmaceuticalDrug Delivery SystemsDrug LiberationReproducibility of ResultsRheologySolubilitySyringesTechnology, Pharmaceutical3D printingdisintegrantgel extrusionorodispersible filmpolymer

Identifiers

PMID41298983
PMCPMC12819439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.