Evidence map›Paper›PMID 41298953›Full record

ArticleActa neurochirurgica2025

The impact of home medications on the risk of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

Pikria Ketelauri, Meltem Gümüs, Hanah Hadice Karadachi, Anna Michel, Aigerim Togyzbayeva, Laurèl Rauschenbach, Nika Guberina, Cornelius Deuschl, Yan Li, Marvin Darkwah Oppong and 4 more

Abstract read
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In one paragraph

Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pikria KetelauriDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany. pikria.ketelauri@uk-essen.de.ORCID http://orcid.org/0000-0001-9297-9030
Meltem GümüsDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Hanah Hadice KaradachiDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Anna MichelDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Aigerim TogyzbayevaDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Laurèl RauschenbachDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Nika GuberinaDepartment of Radiotherapy, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Cornelius DeuschlInstitute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Yan LiInstitute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Marvin Darkwah OppongDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Yahya AhmadipourDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Philipp DammannDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Ulrich SureDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Ramazan JabbarliDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDelayed cerebral ischemia (DCI) is one of the most severe complications following aneurysmal subarachnoid hemorrhage (SAH) and can significantly worsen clinical outcomes. This study aimed to analyze the association between patients' home medications and the risk of cerebral infarction and poor functional outcomes after SAH.

methodsThis retrospective analysis included 995 patients with aneurysmal SAH treated at our clinic between January 2003 and June 2016. Various demographic and clinical baseline characteristics were examined, with a particular focus on regular use of home medications. The study endpoints were the occurrence of early (within 72 h post-SAH) and DCI-related infarcts (> 72 h) in follow-up computed tomography scans, as well as the functional disability at six months, defined as a modified Rankin Scale > 2.

resultsThere was no association between the occurrence of early infarcts and patients' regular medications. In contrast, individuals with calcium channel blockers (CCB) use (n = 93) showed a higher rate of DCI (32.6% vs 19.3%, p = 0.005) and 6-months functional disability (57.8% vs 46.8%, p = 0.048). In multivariable analysis, CCB use was independently associated with the risk of DCI (adjusted odds ratio [aOR] = 4.05; p < 0.0001) and functional disability after six months (aOR = 2.73; p = 0.036).

conclusionsRegular CCB use was independently associated with an increased risk of DCI and functional disability at six months. These findings warrant cautious interpretation and further validation in prospective studies.

Indexed as

Brain IschemiaCalcium Channel BlockersSubarachnoid HemorrhageAdultAgedCerebral InfarctionFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsCalcium Channel BlockersAneurysmal subarachnoid hemorrhageCerebral infarctionDelayed cerebral ischemiaHome medications

Identifiers

PMID41298953
PMCPMC12660461

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.