Evidence map›Paper›PMID 41298770›Full record

Observational studyScientific reports2025

Association of chemotherapy and stoma features with peristomal skin disorders in rectal cancer patients.

Takuya Shiraishi, Yuji Nishizawa, Mifumi Nakajima, Ryoko Kado, Hiroomi Ogawa, Satoh Naomi, Yohei Owada, Tsuyoshi Enomoto, Shinji Yazawa, Yukihiro Hamahata and 10 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Takuya ShiraishiDepartment of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Japan. tashirai@gunma-u.ac.jp.
Yuji NishizawaDepartment of Colorectal Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Mifumi NakajimaDepartment of Nursing, National Cancer Center Hospital East, Kashiwa, Japan.
Ryoko KadoDepartment of Nursing, National Cancer Center Hospital East, Kashiwa, Japan.
Hiroomi OgawaDepartment of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Japan.
Satoh NaomiDepartment of Nursing, Gunma University Hospital, Maebashi, Japan.
Yohei OwadaDepartment of Gastrointestinal and Hepatobiliary Pancreatic Surgery, University of Tsukuba, Tsukuba, Japan.
Tsuyoshi EnomotoDepartment of Gastrointestinal and Hepatobiliary Pancreatic Surgery, University of Tsukuba, Tsukuba, Japan.
Shinji YazawaDepartment of Nursing, University of Tsukuba Hospital, Tsukuba, Japan.
Yukihiro HamahataDepartment of Colorectal Surgery, Tsujinaka Hospital Kashiwanoha, Kashiwa, Japan.
Yumi IsogamiDepartment of Nursing, Tsujinaka Hospital Kashiwanoha, Kashiwa, Japan.
Kazuo KitagawaDepartment of Surgery, The Jikei University Kashiwa Hospital, Kashiwa, Japan.
Maki SakamotoDepartment of Nursing, The Jikei University Kashiwa Hospital, Kashiwa, Japan.
Hiroya EnomotoDepartment of Surgery, The Jikei University Daisan Hospital, Komae, Japan.
Akiko EgawaDepartment of Nursing, The Jikei University Hospital, Tokyo, Japan.
Daichi KitaguchiDepartment of Colorectal Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Hiro HasegawaDepartment of Colorectal Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Koji IkedaDepartment of Colorectal Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Yuichiro TsukadaDepartment of Colorectal Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Masaaki ItoDepartment of Colorectal Surgery, National Cancer Center Hospital East, Kashiwa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to identify factors associated with the onset and worsening of peristomal skin disorders during outpatient follow-up after stoma creation for malignant rectal tumors. This prospective multicenter observational study enrolled patients who underwent stoma creation for malignant rectal tumors between December 2019 and December 2021 at six Japanese institutions. Patients were evaluated using the ABCD-Stoma and DET scoring systems at 1 month and during subsequent follow-up visits. A total of 130 patients were analyzed. At the 1-month visit, 53 (40.8%) had no peristomal skin disorders and 77 (59.2%) had lesions. Multivariate analysis showed that chemotherapy (odds ratio [OR] = 17.50, 95% confidence interval [CI]: 1.76-174.27, p = 0.015), loop stoma (OR = 43.46, 95%CI 1.70-1113.99, p = 0.023), and stoma height < 10 mm (OR = 32.68, 95%CI: 1.94-549.55, p = 0.015) were independently associated with the development of peristomal skin disorders. Diabetes mellitus (OR = 4.26, 95%CI: 1.08-16.79, p = 0.039) was independently associated with worsening, whereas stoma height < 10 mm (OR = 5.85, 95%CI: 1.16-29.35, p = 0.032) was associated with severe lesions during follow-up. These findings highlight the importance of continuous outpatient monitoring and tailored stoma-care support to facilitate early detection and management of peristomal skin disorders, especially in high-risk patients.

Indexed as

Antineoplastic AgentsRectal NeoplasmsSkin DiseasesSurgical StomasAdultAgedAged, 80 and overFemaleHumansJapanMaleMiddle AgedProspective StudiesAntineoplastic AgentsChemotherapy-induced complicationsColorectal neoplasmsDiabetes mellitusPeristomal skin complicationsStoma care

Identifiers

PMID41298770
PMCPMC12657503

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.