ArticleScientific reports2025
Dysbiosis of gut microbiota in children with functional constipation and damp-heat constitution: a cross-sectional multi-omics analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- [Research progress of metabolomics in the pathogenesis and treatment of constipation in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
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9 authors.
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Abstract
Functional constipation (FC), a prevalent gastrointestinal disorder in early childhood associated with gut microbial dysbiosis, shows significant connections with specific constitutional types in Traditional Chinese Medicine (TCM). While TCM's nine constitutional classifications identify damp-heat constitution as a potential risk factor for FC, pediatric-specific evidence remains scarce regarding this correlation. Using the Constitutional Medicine Questionnaire, 49 children under 2 years were stratified into two groups: 18 children with damp-heat constitution who suffered from constipation (DHC) and 31 children with balanced constitution who did not suffer from constipation (BC). Clinical assessments (Bristol Stool Scale, symptom profiles), gut microbial profiling (16 S rRNA sequencing), and urinary metabolomics (UPLC-Q-TOF/MS) revealed marked intergroup differences. DHC subjects demonstrated reduced stool consistency scores, heightened symptom severity, distinct microbial communities, and altered sphingolipid-related metabolic pathways. A diagnostic panel combining six microbial markers and six metabolites achieved effective discrimination. This multi-omics investigation delineates the pathophysiological characteristics of FC in DHC children, proposing novel therapeutic targets through TCM constitution-based microbial-metabolite interactions.
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