ArticleScientific reports2025
Assessment of platelet indices, beta-thromboglobulin and platelet factor IV in platelet concentrate at University of Ilorin Teaching Hospital, Nigeria.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Platelet concentrate transfusion remains a major therapeutic care for patient with hematological disorders. However, optimal therapeutic effect has been a major challenge. Blood donor characteristics and processing procedure remain major areas of research. Hence, this research assessed the platelet functional parameters, beta-thromboglobulin and Platelets factor IV in donors and platelet concentrate. The study was a cross-sectional descriptive study among prospective blood donors for platelet concentrate. Seventy-one prospective blood donors were recruited for this study with mean age of 34.8. Whole blood and aliquot from concentrate were collected for platelet functional parameters using Semi-automated Haematology analyzer, pH using potentiometric method while Beta-thromboglobulin and Platelet factor IV using ELISA-based assays. There was high quality prospective blood donors recruited for platelet concentrate for the current study. Furthermore, there was significant increase (P-value < 0.00) in platelet count, plateletcrit (PCT), β-thromboglobulin (BTG), Platelets factor IV (PF4) and platelet large cell concentration (PLCC) in the first 12 h of harvest and running through 5 days of storage as pre-transfusion relative to the baseline values. Conversely, there was significant decrease in Mean platelet volume (MPV), platelet distribution width coefficient of variation (PDW-CV) and Platelet large cell ratio (P-LCR). Interestingly, fall in pH for the first 12 h was significant compared to 5 days longitudinal drop in pH. These findings indicate a slight but steady increase in platelet activation markers as storage time progresses. Platelets in Platelet concentrates were of low therapeutic quality due to significant platelet activation however, transfusion within 2 h of harvest and not more than 6 h post-harvest can guarantee better patient outcome. The study further established significance of including pH in evaluating platelet concentrates pre-transfusion to optimize transfusion outcome if transfusion is delayed beyond 6 h post-harvest.
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