Evidence map›Paper›PMID 41298576›Full record

ArticleScientific reports2025

Rat models of lactose intolerance: sexually dimorphic comorbidities with neuropsychiatric disorders modulated by tryptophan hydroxylase and the dopaminergic system.

Marcella C Galvão, Nathalia A Galvão, Vanessa S A da Silva, Tifany V Rocha, Daniel N L Santos, Liebert B Carvalho, Rodrigo A F da Silva, Thiago Berti Kirsten

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marcella C GalvãoPsychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, São Paulo, 1212, 04026-002, SP, Brazil.
Nathalia A GalvãoPsychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, São Paulo, 1212, 04026-002, SP, Brazil.
Vanessa S A da SilvaPsychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, São Paulo, 1212, 04026-002, SP, Brazil.
Tifany V RochaPsychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, São Paulo, 1212, 04026-002, SP, Brazil.
Daniel N L SantosPsychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, São Paulo, 1212, 04026-002, SP, Brazil.
Liebert B CarvalhoDentistry, University of Taubaté, Taubaté, São Paulo, SP, Brazil.
Rodrigo A F da SilvaCenter for Epigenetic Study and Genic Regulation, Program in Environmental and Experimental Pathology, Paulista University, São Paulo, Brazil.
Thiago Berti KirstenPsychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, São Paulo, 1212, 04026-002, SP, Brazil. thik@outlook.com.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo #2024/05651-4
6 · The paper itself

Abstract

Some studies indicate a sexually dimorphic effect, along with a potential predisposition to neuropsychiatric disorders in patients with lactose intolerance. This study proposed rat models of lactose intolerance, evaluating the manifestation of behaviors related to neuropsychiatric disorders, their incidence in each sex, and the underlying neurobiological processes. Rats were exposed to two lactose-rich diets: a solution containing 14% lactose and a commercial milk formula. Clinical signs were monitored. Behavioral tests for anxiety (light-dark box), social preference, and depression (forced swim test) were conducted. Brain dopamine levels and genetic and epigenetic (DNA methylation) expressions of tryptophan hydroxylase (Tph)1 in the intestine were also examined. Both diets were well consumed and led to impaired stool consistency. Males exhibited anxiolytic-like behavior, increased striatal dopamine levels, and decreased cortical dopamine levels after consuming the lactose solution. In contrast, females showed anxiogenic-like behavior and decreased cortical dopamine levels following the commercial formula. Male socialization was impaired by both diets. Furthermore, both diets reduced Tph1 gene expression. In conclusion, this study introduced two rat models of lactose intolerance that revealed sexually dimorphic comorbidities with neuropsychiatric disorders, along with modulation of striatal and cortical dopaminergic systems and reduced genetic expression of the Tph1 enzyme in the intestine.

Indexed as

DopamineLactose IntoleranceMental DisordersTryptophan HydroxylaseAnimalsAnxietyBehavior, AnimalComorbidityDisease Models, AnimalFemaleMaleRatsSex CharacteristicsDopaminetph1 protein, ratTryptophan HydroxylaseAnxietyBehaviorBrainIntestineLactase non-persistenceMonoamines

Identifiers

PMID41298576
PMCPMC12658057

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.