Evidence map›Paper›PMID 41298510›Full record

ArticleNPJ Parkinson's disease2025

Transcranial static magnetic field stimulation of the primary motor cortex in essential tremor: a randomized pilot study.

Daniele Urso, Mariana H G Monje, Beatriz Fernández-Rodríguez, Lydia Vela-Desojo, Antonio Oliviero, Guglielmo Foffani, Claudia Ammann

Registry-linked trialAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03780426 (Transcranial Static Magnetic Field Stimulation), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03780426 phase2completednot on this map

Transcranial Static Magnetic Field Stimulation (tSMS) in Essential Tremor

TypeinterventionalSponsorFundación de investigación HMRan2018 to 2019Enrolled30ConditionsEssential TremorArmstSMS, sham
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniele UrsoHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain.
Mariana H G MonjeHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain.
Beatriz Fernández-RodríguezHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain.
Lydia Vela-DesojoHospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain.
Antonio OlivieroFENNSI Group, Hospital Nacional de Parapléjicos, Toledo, Spain; Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Spain.
Guglielmo FoffaniHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain. gfoffani.hmcinac@hmhospitales.com.
Claudia AmmannHM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain. cammann.hmcinac@hmhospitales.com.

Funding

"la Caixa" Foundation LCF/PR/ HR20/52400012Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación IJC2020-04 5437-IMinisterio de Ciencia e Innovación, Agencia Estatal de Investigación PID2021-128623OB-I00
6 · The paper itself

Abstract

Alterations in the motor cortex may contribute to essential tremor (ET) pathophysiology. Transcranial static magnetic field stimulation (tSMS), a non-invasive and portable technique, reduces corticospinal excitability, but its therapeutic potential for ET remains untested. This randomized, double-blind pilot study (clinicaltrials.gov#: NCT03780426, registered on December 19, 2018) investigated the acute effects of tSMS applied to the primary motor cortex in 27 ET patients (mean age: 66.9 ± 12.1 years). Patients received a 30-min tSMS session on either the left (n = 13) or right (n = 14) hemisphere. Postural tremor was assessed by accelerometry, and kinetic tremor by part B of the Clinical Rating Scale for Tremor. Twenty-three patients were included in the final analysis for primary and secondary outcomes. Bayesian analysis showed moderate evidence for a bilateral reduction in postural and rest tremor following unilateral tSMS, with anecdotal reduction of kinetic tremor and moderate evidence of absence of change in tremor frequency. These preliminary findings warrant further studies to assess tSMS as a therapeutic option for ET.

Identifiers

PMID41298510
PMCPMC12658149

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.