Oxidative stress indicators mediated the association of dietary copper intake with low muscle mass: a cross-sectional study.

Lin Wen, Xiaofan Xu, Jianhe Guo, Yuxiao Liao, Nanpeng Zhao, Liangkai Chen, Jun Wang, Liegang Liu

Abstract read

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Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Lin Wen *Hubei Key Laboratory of Food Nutrition and Safety, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Xiaofan Xu *Hubei Key Laboratory of Food Nutrition and Safety, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Jianhe GuoHubei Key Laboratory of Food Nutrition and Safety, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Yuxiao LiaoHubei Key Laboratory of Food Nutrition and Safety, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Nanpeng ZhaoHubei Key Laboratory of Food Nutrition and Safety, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Liangkai ChenHubei Key Laboratory of Food Nutrition and Safety, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Jun WangSchool of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China. junwangwh@hotmail.com.

Liegang LiuHubei Key Laboratory of Food Nutrition and Safety, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lgliu@mails.tjmu.edu.cn.

Funding

National Natural Science Foundation of China NSFC82304153the Fundamental Research Funds for the Central Universities YCJJ20251404

6 · The paper itself

Abstract

This study aimed to investigate the association between dietary copper intake and muscle mass. Low muscle mass was defined according to the Foundation for the National Institutes of Health (FNIH) consensus. Among 9693 adults (female 50.3%), mean age was 39.5 ± 0.3 years, and mean copper intake was 1.2 ± 0.01 mg/day. Compared to the lowest quintile, participants in the highest quintile of copper intake exhibited a decreased risk of low muscle mass (OR = 0.43; 95% CI: 0.26, 0.72). For per 0.5 mg/day increase in copper intake, the risk of low muscle mass was decreased by 20% (P < 0.05). This association was mediated by serum albumin, bilirubin, and gamma-glutamyl transferase, with mediating proportions of 5.92%, 2.84%, and 2.56% respectively (P < 0.001). In summary, increasing copper intake may serve as a protective factor to prevent muscle loss, and oxidative stress may be crucial to this process.

Identifiers

PMID41298495

DOI10.1038/s41538-025-00645-y

PMCPMC12749745

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