Evidence map›Paper›PMID 41298479›Full record

ArticleNature communications2025

Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1).

Tianle Chen, Francesca Vallese, Eva Gil-Iturbe, Kookjoo Kim, Tito Calì, Matthias Quick, Oliver B Clarke, Emad Tajkhorshid

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianle Chen *Theoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois, Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0001-6581-8012
Francesca Vallese *Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA.
Eva Gil-IturbeDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-4046-5756
Kookjoo KimDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA.
Tito CalìDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Matthias QuickDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-8620-827X
Oliver B ClarkeDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA. oc2188@cumc.columbia.edu.ORCID 0000-0003-1876-196X
Emad TajkhorshidTheoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois, Urbana-Champaign, Urbana, IL, USA. emad@illinois.edu.ORCID 0000-0001-8434-1010

Funding

WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
Resource for Macromolecular Modeling and VisualizationR24GM145965 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Emad Tajkhorshid · 2022 to 2026
$6.2M
Molecular mechanism of Na+ -coupled HCO3- transporters: transport of CO3= and CO2R01DK128315 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI BORON, WALTER F, TAJKHORSHID, EMAD · 2021 to 2024
$2.7M
Architecture, dynamics and regulation of erythrocyte ankyrin-1 complexesR01HL168178 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Oliver Biggs Clarke · 2023 to 2026
$2.4M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) P41-GM104601Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01-DK128315Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01-HL168178Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R24-GM145965NHLBI NIH HHS R01 HL168178NIDDK NIH HHS R01 DK128315NIGMS NIH HHS P41 GM104601NIGMS NIH HHS R24 GM145965
6 · The paper itself

Abstract

Anion Exchanger 1 (AE1) is an elevator-type transporter that plays a key role in acid-base homeostasis of erythrocytes. Here, we report three high-resolution cryo-electron microscopy (cryo-EM) structures of distinct states of AE1: two inward-facing (IF1 and IF2) and one outward-facing (OF). Uptake assay revealed the modulatory effect of phosphatidylinositol 4,5-bisphosphate (PIP

Indexed as

Anion Exchange Protein 1, ErythrocyteLipidsPhosphatidylinositol 4,5-DiphosphateAnionsBicarbonatesBinding SitesCryoelectron MicroscopyHumansMolecular Dynamics SimulationProtein ConformationAnion Exchange Protein 1, ErythrocyteAnionsBicarbonatesLipidsPhosphatidylinositol 4,5-DiphosphateSLC4A1 protein, human

Identifiers

PMID41298479
PMCPMC12748791

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.