ArticleNature communications2025
Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- High-frequency visual stimulation can increase medial temporal lobe ripple oscillation density.Communications medicine · 2026Article
- Review
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Aperiodic 1/f noise drives ripple activity in humans.Nature communications · 2026Article
- LFP-LOC: an LFP power-based method for validating the anatomical placement of high-density neural probes in rodents.Frontiers in neuroscience · 2026Article
- Dissociating physiological ripples and epileptiform discharges with vision transformers.bioRxiv : the preprint server for biology · 2025Article
- How Can Animal Models Advance Research into High Frequency Oscillations: Guidelines for Recording, Detection and Analysis.Epilepsy currentsReview
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Authors and funding
9 authors.
Funding
Abstract
Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation. Despite extensive characterization in rodents, their detection in humans is limited by coarse spatial sampling, interictal epileptiform discharges (IEDs), and a lack of consensus on human ripple localization and morphology. Here, we demonstrate that mouse and human hippocampal ripples share spatial, spectral and temporal features, which are clearly distinct from IEDs. In recordings from male APP/PS1 mice, SPW-Rs were distinguishable from IEDs by multiple criteria. Hippocampal ripples recorded during NREM sleep in female and male surgical epilepsy patients exhibited similar narrowband frequency peaks and multiple ripple cycles in the CA1 and subiculum regions. Conversely, IEDs showed a broad spatial extent and wide-band frequency power. We developed a semi-automated, ripple curation toolbox (ripmap) to separate event waveforms by low-dimensional embedding to reduce false-positive rate in selected ripple channels. Our approach improves ripple detection and provides a firm foundation for future human memory research.
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