Evidence map›Paper›PMID 41298360›Full record

ArticleNature communications2025

Light-driven radical copper-catalyzed allylic amination via allylic copper intermediates.

Hang Luo, Yupeng Yang, Yunpeng Ma, Fangnian Yu, Min Gao, Shizhao Xu, Huawei Ju, Yang Li, Kaifeng Wu, Luqing Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hang Luo *Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
Yupeng Yang *State Key Laboratory of Chemical Reaction Dynamics and Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China.
Yunpeng Ma *Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
Fangnian YuCentral Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
Min GaoInstitute for Chemical Reaction Design and Discovery (ICReDD), Hokkaido University, Sapporo, Hokkaido, Japan. gaomin@icredd.hokudai.ac.jp.ORCID http://orcid.org/0000-0002-7263-1157
Shizhao XuCentral Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China.
Huawei JuState Key Laboratory of Fine Chemicals, Dalian University of Technology, Liaoning, China.
Yang LiState Key Laboratory of Fine Chemicals, Dalian University of Technology, Liaoning, China.ORCID http://orcid.org/0000-0002-5719-9044
Kaifeng WuState Key Laboratory of Chemical Reaction Dynamics and Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China. kwu@dicp.ac.cn.ORCID http://orcid.org/0000-0002-1047-6606
Luqing LinCentral Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China. linluqing@dlut.edu.cn.ORCID http://orcid.org/0000-0002-4738-0886

Funding

Chinese Academy of Sciences (CAS) YSBR-007
6 · The paper itself

Abstract

The synthesis of allylic amines through an outer-sphere nucleophilic substitution mechanism involving electrophilic allyl copper(III) complexes with soft amines represents an uncharted territory in catalysis. This study introduces a radical-based approach for the generation of allylic copper(III) complexes, enabling the efficient synthesis of allylic amines in the presence of alkyl/aryl amines. Through copper photocatalysis, we demonstrate a radical-induced small-ring opening process that produces allylic amines featuring skipped double bonds, while simultaneously achieving highly regioselective 1,4-carboamination of 1,3-dienes with high E/Z selectivity. Mechanism studies substantiate the radical-mediated formation of allylic copper complexes and provide evidence for the involvement of outer-sphere nucleophilic substitution at allylic copper(III) complexes.

Identifiers

PMID41298360
PMCPMC12657895

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