ArticleAnnals of Indian Academy of Neurology2025
Diagnostic Potential of Cerebrospinal Fluid Biomarkers in Diagnosis of Primary Central Nervous System Lymphoma: A Systematic Review and Meta-Analysis.
Article in Annals of Indian Academy of Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary central nervous system lymphoma (PCNSL) is an aggressive form of non-Hodgkin's lymphoma primarily restricted to the brain, spinal cord, eyes, and leptomeninges without any evidence of systemic spread. It is often challenging to diagnose PCNSL due to its clinical and radiological overlap with various central nervous system (CNS) inflammatory conditions and other brain tumors. Cytokines and chemokines in cerebrospinal fluid (CSF) have shown potential as biomarkers for PCNSL, but the conclusion on their diagnostic utility is unavailable. This study intended to assess the role of CSF cytokines and chemokines in differentiating PCNSL from other CNS disorders.
methodsWe searched electronic databases extensively to find studies that examined the sensitivity and specificity of CSF cytokine or chemokine levels in PCNSL-synthesizing results involved standardizing the units of measurement where necessary and verifying data accuracy. Pooled effect estimates were computed by meta-analyses utilizing random-effects models.
resultsA total of 12 studies were included. The increased levels of CSF interleukin (IL)-10 and C-X-C motif Chemokine Ligant 13 (CXCL 13) were significantly associated with a positive diagnosis of PCNSL. Diagnostic accuracy measures demonstrated the promising discriminatory power of CSF IL-10 and IL-10:IL-6 ratio.
conclusionOur findings revealed considerable diversity in the diagnostic accuracy of individual biomarkers. Notably, CSF IL-10 and CSF IL-10:IL-6 ratios exhibited the highest pooled specificity and sensitivity, suggesting their promising potential as a diagnostic marker for PCNSL.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.