Evidence map›Paper›PMID 41298226›Full record

ArticleAnnals of medicine2025

Chlorogenic acid mitigates acute respiratory distress syndrome via inhibition of the PI3K/AKT signalling pathway: an integrated analysis of bioinformatics and validation experiments.

Jie Wei, Guan Ye Nai, Min Wu, Yu Mei Huang, Zhao Ping Gan, Zhen Bin Wei, Hui Li, Wei Jie Zhou, Rong Rong Liu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie WeiDepartments of Hematology, the First Affiliated Hospital of Guangxi Medical University, China.
Guan Ye NaiDepartments of hematology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Min WuDepartments of Hematology, the First Affiliated Hospital of Guangxi Medical University, China.
Yu Mei HuangDepartments of Hematology, the First Affiliated Hospital of Guangxi Medical University, China.
Zhao Ping GanDepartments of Hematology, the First Affiliated Hospital of Guangxi Medical University, China.
Zhen Bin WeiDepartments of Hematology, the First Affiliated Hospital of Guangxi Medical University, China.
Hui LiDepartment of Intensive Care Unit, Baise people's hospital, China.
Wei Jie ZhouCentral Laboratory, Baise People's Hospital, China.
Rong Rong LiuDepartments of Hematology, the First Affiliated Hospital of Guangxi Medical University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHigh mortality rates are linked to acute respiratory distress syndrome (ARDS), a prevalent type of respiratory failure. Amid the COVID-19 outbreak in particular, a viable defensive method is provided by traditional Chinese medicine (TCM). This study investigated whether chlorogenic acid (CGA), a primary component of honeysuckle, could protect against ARDS.

methodsWe employed network pharmacology to explore the honeysuckle and ARDS component-target-disease network, and enrichment function analysis to uncover the potential mechanisms of honeysuckle in treating ARDS. LPS-induced ARDS rat models (each group rats

resultsWe identified 144 common drug-disease targets, with honeysuckle containing 23 potentially active components. Key genes included STAT3, PIK3CA, and AKT1, which are involved in the PI3K/AKT, HIF-1, and Ras signalling pathways. Compared to the control group,

conclusionCGA alleviates ARDS by inhibiting the PI3K/AKT signaling pathway, thereby suppressing inflammation, regulating T-cell subtypes, and reducing NET formation.

Indexed as

Chlorogenic AcidProto-Oncogene Proteins c-aktRespiratory Distress SyndromeAnimalsComputational BiologyCOVID-19Disease Models, AnimalLoniceraMaleMolecular Docking SimulationNetwork PharmacologyPhosphatidylinositol 3-KinasesRatsRats, Sprague-DawleySignal TransductionChlorogenic AcidPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktacute respiratory distress syndromeanti-inflammationChlorogenic acidneutrophil extracellular trapPI3K/AKT signaling pathway

Identifiers

PMID41298226
PMCPMC12667327

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.