Evidence map›Paper›PMID 41298205›Full record

Trial reportJournal of the National Medical Association2026

Physician referral is associated with recruitment, motivation, and adherence in an exercise intervention study for older adults.

Rachel Holden, Amanda N Szabo-Reed, Amber Watts, Jonathan Clutton, Katrina Finley, Sharon Fitzgerald Wolff, Jeffrey M Burns

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the National Medical Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03253341 (Prescribing Smart Aging), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03253341 nacompletednot on this map

Prescribing Smart Aging: Integrating Health Systems With Community-Based Lifestyle Interventions

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2018 to 2023Enrolled219ConditionsAging, Health BehaviorArmsSmart Aging Program, Educational Materials
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rachel HoldenKU Alzheimer's Disease Research Center, Fairway, KS, 66205 USA.
Amanda N Szabo-ReedKU Alzheimer's Disease Research Center, Fairway, KS, 66205 USA; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA. Electronic address: aszabo@kumc.edu.
Amber WattsKU Alzheimer's Disease Research Center, Fairway, KS, 66205 USA; Department of Psychology, University of Kansas, Lawrence, KS, 66045, USA.
Jonathan CluttonKU Alzheimer's Disease Research Center, Fairway, KS, 66205 USA.
Katrina FinleyKU Alzheimer's Disease Research Center, Fairway, KS, 66205 USA.
Sharon Fitzgerald WolffDepartment of Population Health, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Jeffrey M BurnsKU Alzheimer's Disease Research Center, Fairway, KS, 66205 USA; Department of Neurology, University of Kansas Medical Center, Kansas City, KS, 66103, USA.

Funding

RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3M
University of Kansas Alzheimer's Disease Research Center (KU ADRC)P30AG072973 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Robyn A Honea · 2021 to 2026
$25.3M
Institutional Career Development CoreKL2TR002367 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MATTHEW W MOSCONI, NICOLE L NOLLEN · 2017 to 2026
$7.3M
Prescribing Smart Aging: Integrating Health Systems with Community-Based Lifestyle InterventionsR01AG052954 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BURNS, JEFFREY MURRAY · 2017 to 2021
$2.9M
NCATS NIH HHS KL2 TR002367NCATS NIH HHS UL1 TR002366NIA NIH HHS P30 AG072973NIA NIH HHS R01 AG052954
6 · The paper itself

Abstract

objectiveThe LEAP! Rx study was a 12-month randomized controlled trial investigating the effects of supervised exercise and education. This paper is a secondary-data analysis exploring differences in recruitment, motivation, adherence, and retention between physician-referred and self-referred participants.

methods219 total healthy, older adult participants (72.79 ± 4.83 years), 118 physician-referred and 101 self-referred, were randomized into a structured exercise and education for Alzheimer's Disease prevention ((n = 110, i.e., LEAP! Rx) or a waitlist control group (n = 109). Demographics and patterns in recruitment, motivations for participation, adherence, and retention related to age, gender, race, ethnicity, or education were examined between the physician-referred and self-referred groups.

resultsWe observed a significant difference in race, but not sex, between the two referral methods. Specifically, the physician-referred group had a higher proportion of African American participants. Attendance to education classes was similar for both referral types. However, self-referred participants had better adherence to the exercise prescription and were also less likely to withdraw from the study. A higher number of physician-referred participants withdrew due to COVID-19 or were lost to follow-up, likely due to the timing of their recruitment into the study. Motivations for participation were not significantly different by referral source however, a trend with recognition was associated with physician referral and study withdrawal.

conclusionsFindings suggest that physician referrals can enhance the racial diversity of research participants. The lower adherence in the physician-referred group was likely due to the pandemic's influence on enrollment, highlighting the need for further research on the relationship between recruitment source, motivations, and adherence.

trial registrationNCT03253341.

Indexed as

Alzheimer DiseaseExercise TherapyMotivationPatient CompliancePatient SelectionReferral and ConsultationAgedExerciseFemaleHumansMaleAdherenceAgingExerciseMotivationOlder adultsPhysical activityPhysician referralRecruitment

Identifiers

PMID41298205
PMCPMC13377785

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.