SynthesisCancer reports (Hoboken, N.J.)2025
Brain Metastases in Cervical Cancer: A Global Systematic Review and Meta-Analysis of Incidence and Clinicopathological Features.
Synthesis in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain Metastases in Cervical Cancer: A Global Systematic Review and Meta-Analysis of Incidence and Clinicopathological Features.Cancer reports (Hoboken, N.J.) · 2025Pooled it
- An investigational prognostic framework for stage IVB cervical cancer based on metastatic patterns: a population-based study with exploratory external evaluation.Frontiers in oncology · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundCervical cancer (CC) remains the fourth most prevalent malignancy among women globally, with a disproportionate burden in low- and middle-income countries, where it is often diagnosed at advanced or metastatic stages.
aimsDespite an increasing number of case reports and institutional studies on brain metastases (BMs) arising from CC, current understanding of their epidemiology, clinical presentation, and prognostic implications remains fragmented and lacks comprehensive synthesis.
methodsWe executed a systematic and unrestricted search of five major databases, PubMed/Medline, Scopus, Embase, Web of Science, and Google Scholar, covering all records up to April 19, 2025. Studies were eligible for inclusion if they provided a clear report on the incidence of BMs among CC patients. The quality and risk of bias of the selected studies were independently appraised using the Joanna Briggs Institute (JBI) assessment criteria. For statistical analysis, we utilized STATA version 17, implementing random-effects meta-analytical models to estimate the aggregated incidence along with corresponding 95% confidence intervals (CIs).
resultsA total of 17 studies encompassing 33 datasets were included in the final analysis. The global pooled incidence of BMs among cervical cancer patients was estimated at 0.65% (95% CI: 0.46-0.85). Incidence was highest in Turkey (1.83%, 95% CI: 0.91-2.75) and lowest in South Africa (0.22%, 95% CI: 0.0-0.47). Among histologic subtypes, neuroendocrine carcinoma exhibited the highest pooled incidence of BMs at 10.60% (95% CI: 0.0-21.63), followed by adenocarcinoma at 0.89% (95% CI: 0.14-1.64). The pooled mean survival time following the diagnosis of BMs was 6.80 months (95% CI: 5.08-8.52), while the mean interval from the initial cervical cancer diagnosis to the development of BMs was 28.15 months (95% CI: 24.27-32.03).
conclusionAlthough BMs in cervical cancer are rare, they are associated with dismal survival outcomes and poor prognosis. These findings underscore the importance of vigilant surveillance in high-risk patients and may inform the development of more targeted and effective therapeutic and preventive strategies.
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