Trial reportJournal of the International Society of Sports Nutrition2025
Plasma levels of adrenaline, noradrenaline, dopamine, serotonin, and cortisol in sarcopenia: comparison with non-sarcopenic individuals and the impact of resistance exercise and nutrition interventions.
Trial report in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Bioanalytical HPLC-UV Determination of Dopamine in Plasma and Mouse Brain Homogenate with Greenness, Whiteness, and Blueness Assessment.Molecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcopenia may disrupt the hypothalamic‒pituitary‒adrenal axis, affecting neurotransmitter and hormone levels. However, the impact of sarcopenia on these markers, particularly in comparison to non-sarcopenic controls, is understudied. Additionally, the effects of resistance exercise and nutritional support on neurotransmitter levels in sarcopenic patients are largely unknown. This study explores these neurochemical changes and their response to therapeutic interventions.
methodsThis post hoc analysis of a randomized controlled trial included 57 sarcopenic and 57 non-sarcopenic participants from the same cohort. Grip strength and body composition were measured. Sarcopenic patients received a 12-week intervention involving resistance exercise and supplementation with branched-chain amino acids, calcium, and vitamin D3. Plasma adrenaline, noradrenaline, dopamine, serotonin, and cortisol were assessed using enzyme-linked immunosorbent assay (ELISA).
resultsSarcopenic individuals had significantly lower levels of serotonin (13.28 vs 19.21 ng/mL,
conclusionSarcopenic patients exhibit lower serotonin, adrenaline, and noradrenaline compared to non-sarcopenic controls, with no significant difference in cortisol levels. Resistance exercise and nutritional interventions increased noradrenaline in sarcopenic individuals. Further studies are needed to evaluate the long-term effects on neurotransmitter and hormone levels.
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Registered trials
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