Evidence map›Paper›PMID 41297906›Full record

ArticleJournal of agricultural and food chemistry2025

Chlorogenic Acid Alleviates Ferroptosis Collectively Induced by Lipopolysaccharide and Interleukin-6 in Bovine Mammary Epithelial Cells.

Liping Wang, Yuhao Chen, Xiaoru Yang, Yuze Ma, Ruiyuan Yao, Xiaoou Cheng, Yanfeng Wang, Huifang Hao, Quan Fu, Lili Bao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liping WangState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.ORCID 0000-0002-6087-3669
Yuhao ChenState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
Xiaoru YangState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
Yuze MaState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
Ruiyuan YaoSchool of Basic Medical Science, Inner Mongolia Medical University, Hohhot 010110, China.
Xiaoou ChengSchool of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Yanfeng WangState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
Huifang HaoState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
Quan FuDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
Lili BaoSchool of Basic Medical Science, Inner Mongolia Medical University, Hohhot 010110, China.
Zhigang WangState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.ORCID 0000-0002-6818-2205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipopolysaccharide (LPS) from Gram-negative bacteria is a potent proinflammatory stimulates that drives the production of cytokines, including interleukin 6 (IL-6). Chlorogenic acid (CGA) is a plant-derived compound with potent anti-inflammatory activity. LPS, IL-6, and CGA are involved in programmed cell death and the release of inflammatory cytokines. However, the induction of ferroptosis by LPS and IL-6 in bovine mammary epithelial cells and the protective effects of CGA against this process are not fully understood. Here, LPS activated IL-6 production through a TLR4/CD36-dependent FAK/mTORC1 signaling axis in MAC-T cells. This pathway also mediated ferroptosis and the reduction in milk products induced by LPS and IL-6. CGA effectively mitigated these effects by suppressing ferroptosis. This study provides the novel mechanism whereby LPS orchestrates IL-6 release through the TLR4/CD36/FAK/mTORC1 axis, triggering ferroptosis and impairing milk synthesis in bovine mammary epithelial cells. It establishes CGA as a promising therapeutic agent against bovine mastitis.

Indexed as

Chlorogenic AcidEpithelial CellsFerroptosisInterleukin-6LipopolysaccharidesMammary Glands, AnimalMastitis, BovineAnimalsCattleCell LineFemaleMechanistic Target of Rapamycin Complex 1Signal TransductionToll-Like Receptor 4Chlorogenic AcidInterleukin-6LipopolysaccharidesMechanistic Target of Rapamycin Complex 1Toll-Like Receptor 4chlorogenic acidferroptosisinterleukin-6lipopolysaccharidemilk products

Identifiers

PMID41297906
PMCPMC12874535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.