Evidence map›Paper›PMID 41297587›Full record

Trial reportChest2026

The Effects of Targeted Mild Hypercapnia on Right Ventricular Function After Out-of-Hospital Cardiac Arrest: A Substudy of the Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest Trial.

Mathias Baumann Melberg, Susanne D Rootwelt, Arnljot Flaa, Geir Øystein Andersen, Kjetil Sunde, Glenn Eastwood, Rinaldo Bellomo, Theresa M Olasveengen, Eirik Qvigstad

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03114033 (TAME Cardiac Arrest Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03114033 naunknown statusnot on this map

TAME Cardiac Arrest Trial: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial

TypeinterventionalSponsorAustralian and New Zealand Intensive Care Research CentreRan2018 to 2022Enrolled1,700ConditionsOut-Of-Hospital Cardiac ArrestArmsTargeted therapeutic mild hypercapnia, Targeted normocapnia (Standard care)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mathias Baumann MelbergDivision of Emergencies and Critical Care, Department of Research and Development, Oslo, VIC, Norway; Division of Medicine, Department of Cardiology, Oslo, VIC, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, VIC, Norway. Electronic address: mb.melberg@gmail.com.
Susanne D RootweltDivision of Medicine, Department of Cardiology, Oslo, VIC, Norway.
Arnljot FlaaDivision of Medicine, Department of Cardiology, Oslo, VIC, Norway.
Geir Øystein AndersenDivision of Medicine, Department of Cardiology, Oslo, VIC, Norway.
Kjetil SundeDivision of Emergencies and Critical Care, Department of Anaesthesiology and Intensive Care, Oslo University Hospital, Oslo, VIC, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, VIC, Norway.
Glenn EastwoodDepartment of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.
Rinaldo BellomoDepartment of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.
Theresa M OlasveengenDivision of Emergencies and Critical Care, Department of Anaesthesiology and Intensive Care, Oslo University Hospital, Oslo, VIC, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, VIC, Norway.
Eirik QvigstadDivision of Medicine, Department of Cardiology, Oslo, VIC, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTargeting hypercapnia during invasive mechanical ventilation with subsequent respiratory acidosis may impair right ventricular (RV) function and cause RV failure. RV dysfunction is common after cardiac arrest and may be associated with poor outcomes. RESEARCH QUESTION: Does targeting mild hypercapnia after out-of-hospital cardiac arrest (OHCA) adversely affect RV function, and is RV failure after OHCA associated with increased mortality? STUDY DESIGN AND

methodsIn this single-center, preplanned substudy of the Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest (TAME) trial, patients were randomized to mild hypercapnia (Paco

resultsA total of 111 patients were randomized and evaluated with echocardiography. RHC was performed in 84 patients. TAPSE similarly was reduced in both treatment groups at ICU admission. During the intervention, TAPSE, S', and FAC were higher in the hypercapnia group (P < .05). Accordingly, 13 patients (25%) in the hypercapnia group demonstrated RV systolic dysfunction compared with 37 patients (64%) in the normocapnia group (P < .001). RV failure was present in 30 patients: 8 patients in the hypercapnia group and 22 patients in the normocapnia group (P = .011). RV failure was associated with increased 6-month mortality (hazard ratio, 2.89; 95% CI, 1.37-6.10; P = .005).

interpretationAmong patients resuscitated from OHCA, targeting mild hypercapnia compared with normocapnia was not associated with worsened RV function, but rather with less RV dysfunction and failure. RV failure was associated with increased 6-month mortality. CLINICAL

trial registrationClinicalTrials.gov; No.: NCT03114033; URL: www. CLINICALTRIALS: gov.

Indexed as

Cardiopulmonary ResuscitationHypercapniaOut-of-Hospital Cardiac ArrestVentricular Dysfunction, RightVentricular Function, RightAgedCardiac CatheterizationEchocardiographyFemaleHumansMaleMiddle Agedhypercapnialow tidal volume ventilationout-of-hospital cardiac arrestright ventricular failureright ventricular functionTAME cardiac arrest trial

Identifiers

PMID41297587
PMCPMC13494458

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.