ArticleNeuron2026
Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states.
Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations.Cell reports · 2026Article
- Decomposing the modulation of interactions between neuronal populations.bioRxiv : the preprint server for biology · 2026Article
- The anterior cingulate cortex modulates pupil-linked arousal.Science advances · 2026Article
- Experience-Dependent Plasticity to Visual Sequences in Mouse Anterior Cingulate Cortex Reflects Familiarity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Highly selective visual receptive fields in mouse frontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
The mammalian prefrontal cortex (PFC) is thought to modulate cortical sensory processing during behavior through long-range feedback projections. Subregions of the PFC, such as the anterior cingulate cortex (ACA) and ventrolateral orbitofrontal cortex (ORB), exhibit unique patterns of connectivity that may confer distinct roles in feedback modulation of sensory information. Here, we combined axonal tracing, two-photon calcium imaging, and chemogenetic manipulations in mice to determine how projections from the ACA and ORB influence visual processing in the primary visual cortex (VISp). We found that ACA axons conveyed stronger visual-stimulus information than ORB axons, though both conveyed non-visual, behavior-related information. ACA input enhanced visual encoding in VISp neurons and scaled with behavioral arousal, whereas ORB input shaped behavior-related modulation but reduced high-contrast visual encoding. These results reveal distinct feedback roles of ACA and ORB projections, supporting the modular organization of PFC feedback modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.