Evidence map›Paper›PMID 41297527›Full record

ReviewThe journal of gene medicine2025

The Role of the CLIC/GEEC Endocytic Pathway for Mechanophysical Transfection of DNA.

Sean Weaver, Emran O Lallow, Kelly Kyker-Snowman, Nandita C Jhumur, Melissa Gulley, Christine C Roberts, David I Shreiber, Hao Lin, Joel N Maslow

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of gene medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sean WeaverGeneOne Life Science, Inc., Seoul, Republic of Korea.
Emran O LallowDepartment of Mechanical Engineering and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.
Kelly Kyker-SnowmanDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.
Nandita C JhumurDepartment of Mechanical Engineering and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.
Melissa GulleyGeneOne Life Science, Inc., Seoul, Republic of Korea.
Christine C RobertsGeneOne Life Science, Inc., Seoul, Republic of Korea.
David I ShreiberDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.
Hao LinDepartment of Mechanical Engineering and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.
Joel N MaslowGeneOne Life Science, Inc., Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clathrin-independent carriers/glycosylphosphatidylinositol-attached protein-enriched endosomal compartments (CLIC/GEEC) pathway is a clarithin- and dynamin-independent endocytic pathway. CLIC/GEEC-mediated endocytosis is a large-capacity, rapid-acting process that is utilized by cells for bulk uptake of nutrients and membrane-anchored cargo and for homeostatic maintenance of membrane tension. Here, we present a brief overview of this pathway, including its known molecular mechanisms, inhibitors, activity in different cell types, and its potential relevance in mechanophysical DNA transfection.

Indexed as

DNAEndocytosisEndosomesTransfectionAnimalsClathrinHumansClathrinDNA

Identifiers

PMID41297527
PMCPMC12657061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.