Evidence map›Paper›PMID 41296978›Full record

ArticleOrganic letters2025

Automated Syntheses of Xylan Oligosaccharides Containing β3-Linkages Enable Substrate Specificity Studies of Xylanases from Marine Bacteria.

Nitish Verma, Nils Rustmeier, Uwe Osswald, Fabian Pfrengle

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nitish VermaInstitute of Organic Chemistry, Department of Natural Sciences and Sustainable Resources, BOKU University, Muthgasse 18, 1190 Vienna, Austria.ORCID 0000-0002-4080-8456
Nils RustmeierInstitute of Organic Chemistry, Department of Natural Sciences and Sustainable Resources, BOKU University, Muthgasse 18, 1190 Vienna, Austria.
Uwe OsswaldInstitute of Organic Chemistry, Department of Natural Sciences and Sustainable Resources, BOKU University, Muthgasse 18, 1190 Vienna, Austria.
Fabian PfrengleInstitute of Organic Chemistry, Department of Natural Sciences and Sustainable Resources, BOKU University, Muthgasse 18, 1190 Vienna, Austria.ORCID 0000-0003-2206-6636

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marine polysaccharides, including β3-xylan and mixed-linkage xylan (MLX), play a central role in the ocean's carbon cycle. Using an optimized xylose donor, automated glycan assembly enabled the synthesis of β3- and MLX-oligosaccharides up to decasaccharides. Interrogation of these structurally defined substrates with the marine xylanases Xyl4, AlXyn26A, and MfXyn26A revealed a surprisingly broad substrate scope of MLXases toward both β3-xylan and MLX motifs, highlighting AGA-derived glycans as powerful probes for studying marine polysaccharide metabolism.

Indexed as

BacteriaEndo-1,4-beta XylanasesOligosaccharidesXylansMolecular StructureSubstrate SpecificityEndo-1,4-beta XylanasesOligosaccharidesXylans

Identifiers

PMID41296978
PMCPMC12706835

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.