ArticleScience advances2025
A three-dimensional photoacoustic and ultrasound automated breast volume scanner (PAUS-ABVS) for breast cancer patients.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Photoacoustic imaging of intestinal physiological biomarkers in infants and children.medRxiv : the preprint server for health sciences · 2026Article
- Electrically switchable dual-focus metalens for depth-extended in vivo photoacoustic imaging of ophthalmic vascular disease.Light, science & applications · 2026Article
- Hybrid three-dimensional full-view multi-wavelength photoacoustic and ultrasound breast tomography.Photoacoustics · 2026Article
- Photoacoustic-ultrasound endoscopy for assessment of rectal cancer treatment response: A prospective study with T2-weighted MRI radiomics comparison.Photoacoustics · 2026Article
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- Fully integrated photoacoustic microscopy for multi-scale and longitudinal imaging in translational biomedical applications.Biomedical optics express · 2026Article
- HER2 Score-Aware Virtual Immunohistochemistry via Non-Contrastive Multi-Task Translation.Diagnostics (Basel, Switzerland) · 2026Article
- Volumetric photoacoustic/ultrasound image fusion and enhancement with dual-tree complex wavelet transform.Biomedical optics express · 2026Article
- Ultrasonic modulation of brain glymphatic transport: from observations to theranostic applications.Cancer drug resistance (Alhambra, Calif.) · 2026Review
- Vascular Phenotyping with Photoacoustic and Ultrasound Imaging in Cardiovascular Disease: Recent Innovations.Current treatment options in cardiovascular medicine · 2026Review
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Authors and funding
12 authors.
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Abstract
Breast cancer screening with mammography is less effective in women with dense breast tissue, prompting the use of ultrasound (US) imaging. While two- (2D) and three-dimensional (3D) US improve cancer detection, their low specificity leads to frequent unnecessary biopsies. Operator dependence on 2D US has led to the development of 3D automated breast volume scanners (ABVS), but challenges remain in distinguishing benign from malignant lesions. We developed a 3D photoacoustic and ultrasound (PAUS)-ABVS system that integrates a large field-of-view, 768-element transducer to improve diagnostic accuracy. In a clinical study of 61 patients with 36 benign and 30 malignant lesions, multispectral photoacoustic imaging was used to measure blood volume and oxygen saturation within lesions. When combined with standard US BI-RADS (breast imaging reporting and data system) scores, the system achieved a sensitivity of 96.7% and specificity of 66.7%. This performance matched the best outcomes of 2D PAUS and outperformed conventional US. Our results suggest that the PAUS-ABVS can support more accurate breast cancer diagnosis while reducing unnecessary biopsies.
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