Evidence map›Paper›PMID 41296861›Full record

ArticleScience advances2025

Substitution of human olfaction by the trigeminal system.

Halina B Stanley, Clémentine Lipp, Coralie Mignot, Susanne Weise, Konstantinos Garefis, Maxime Fieux, Evangelia Tsakiropoulou, Sotiria Genetzaki, Romain Dubreuil, Camille Ferdenzi and 8 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Halina B StanleyUniversité Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, NEUROPOP, F-69500 Bron, France.ORCID 0000-0001-6043-4669
Clémentine LippMicrosystems Laboratory, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.ORCID 0000-0002-7361-1385
Coralie MignotDepartment of Otorhinolaryngology, Carl Gustav Carus Faculty of Medicine, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany.ORCID 0000-0002-4763-7186
Susanne WeiseDepartment of Otorhinolaryngology, Carl Gustav Carus Faculty of Medicine, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany.ORCID 0000-0001-7650-1731
Konstantinos Garefis2nd Academic ORL, Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.ORCID 0000-0003-3905-5650
Maxime FieuxHospices civils de Lyon, Hôpital Lyon Sud, Service d'ORL, d'otoneurochirurgie et de chirurgie cervico-faciale, F-69310 Pierre Bénite, France.
Evangelia Tsakiropoulou2nd Academic ORL, Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
Sotiria Genetzaki2nd Academic ORL, Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
Romain DubreuilAryballe, 7 rue des arts et métiers, 38000 Grenoble, France.
Camille FerdenziUniversité Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, NEUROPOP, F-69500 Bron, France.ORCID 0000-0001-5572-0361
Marina CarulliDipartimento di Meccanica, Politecnico di Milano, Via La Masa 1, Milan, Italy.ORCID 0000-0003-2101-5474
Michele BertoliniDipartimento di Meccanica, Politecnico di Milano, Via La Masa 1, Milan, Italy.ORCID 0000-0001-5256-181X
Marco RossoniDipartimento di Meccanica, Politecnico di Milano, Via La Masa 1, Milan, Italy.ORCID 0000-0003-2714-9043
Arnaud BertschMicrosystems Laboratory, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.ORCID 0000-0002-1044-0478
Juergen BruggerMicrosystems Laboratory, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.ORCID 0000-0002-7710-5930
Thomas HummelDepartment of Otorhinolaryngology, Carl Gustav Carus Faculty of Medicine, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany.ORCID 0000-0001-9713-0183
Iordanis Konstantinidis2nd Academic ORL, Head and Neck Surgery Department, Aristotle University of Thessaloniki, Papageorgiou Hospital, Thessaloniki, Greece.
Moustafa BensafiUniversité Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, NEUROPOP, F-69500 Bron, France.ORCID 0000-0002-2991-3036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smell loss is a sensory impairment that has major consequences in many areas of daily life and for which current therapies are insufficient. A prosthesis-type technology enabling patients to sample their olfactory environment has not yet been developed. The aim of our study was, therefore, to test whether stimulation of the intranasal trigeminal system by a device combining an artificial nose with an intranasal electrical stimulator will enable patients to detect and discriminate odorant molecules. Four experiments involving normosmic individuals (

Indexed as

Olfaction DisordersSmellTrigeminal NerveAdultAgedElectric StimulationFemaleHumansMaleMiddle AgedOdorants

Identifiers

PMID41296861
PMCPMC12652247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.