Evidence map›Paper›PMID 41296857›Full record

ArticleScience advances2025

Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in

Yile Zhai, Tiantian Wang, Jiangxue Han, Mengxiao Wu, Meixi Gong, Wenfei Li, Zhe Zhang

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yile ZhaiInstitute of Medical Sciences, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033 Shandong, China.ORCID 0009-0009-9850-8585
Tiantian WangDepartment of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China.ORCID 0009-0008-4360-2518
Jiangxue HanDepartment of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China.
Mengxiao WuDepartment of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China.
Meixi GongDepartment of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China.
Wenfei LiDepartment of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012 Shandong, China.ORCID 0000-0002-5303-4621
Zhe ZhangInstitute of Medical Sciences, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033 Shandong, China.ORCID 0000-0003-3616-6224

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human female fertility declines markedly with age, a pattern mirrored in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsLysosomesProteostasisAnimalsFemaleFertilityMutationOxidative StressReproductionVacuolar Proton-Translocating ATPasesVitellogeninsCaenorhabditis elegans ProteinsVacuolar Proton-Translocating ATPasesVitellogenins

Identifiers

PMID41296857
PMCPMC12652258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.