ArticlePLoS biology2025
Electrical Spinal Imaging: A noninvasive, high-resolution approach that enables electrophysiological mapping of the human spinal cord.
Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Evaluating cardiac noise correction approaches for non-invasive electrophysiology of the human spinal cord.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
The spinal cord is the key bridge between the brain and the body. However, scientific understanding of spinal cord function has historically been limited because noninvasive measures of its neural activity have proven exceptionally challenging. In this work, we describe an enhanced recording and analysis approach, Electrical Spinal Imaging (ESI), to obtain noninvasive, high-resolution images of the electrical activity of the human spinal cord. ESI is analytically simple, easy to implement, and data-driven: it does not involve template-based strategies prone to produce spurious signals. Using this approach, we provide a detailed description and physiological characterization of the spatiotemporal dynamics of the peripheral, spinal, and cortical activity elicited by somatosensory stimulation. We also demonstrate that attention modulates postsynaptic activity at spinal cord level. Our method has enabled five important insights regarding spinal cord activity. (1) We identified three distinct responses in the time domain: sP9, sN13, and sP22. (2) The sP9 is a traveling wave reflecting the afferent volley entering the spinal cord through the dorsal root. (3) In contrast, the sN13 and sP22 reflect segmental postsynaptic activity. (4) While the sP9 response is first seen on the dorsal electrodes ipsilateral to the stimulated side, the sN13 and sP22 were not lateralized with respect to the side of stimulation. (5) Unimodal attention strongly modulates the amplitude of the sP22, but not that of the sP9 and sN13 components. The proposed method offers critical insights into the spatiotemporal dynamics of somatosensory processing within the spinal cord, paving the way for precise noninvasive functional monitoring of the spinal cord in basic and clinical neurophysiology.
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Registered trials
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