Evidence map›Paper›PMID 41296732›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Antibiotics accumulate in

Michelle Angeles-Solano, Zajeba Tabashsum, Jamie D Liu, Zachary J Lifschin, Nikki J Wagner, Kaleb J Tyson, Liang Chen, Rani S Sellers, Kimberly A Walker, Yury Desyaterik and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Antibiotic tolerance coupled with limited benefit from drainage: Clinical challenges inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Reply to Gong et al.: Antibiotic tolerance coupled with limited benefit from drainage: Clinical challenges inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Co-evolution of resistance and virulence inFrontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michelle Angeles-SolanoDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.
Zajeba TabashsumDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.
Jamie D LiuDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.
Zachary J LifschinDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.
Nikki J WagnerDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.ORCID 0000-0002-4872-3107
Kaleb J TysonDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.
Liang ChenDivision of Clinical and Translational Therapeutics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214.ORCID 0000-0001-5845-2235
Rani S SellersDepartment of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599.
Kimberly A WalkerDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.ORCID 0000-0002-6360-2792
Yury DesyaterikEshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599.
Elias P RosenEshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599.
Sarah E RoweDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599.ORCID 0000-0001-8955-359X

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
A theranostic ultrasound approach to improve chronic wound treatment using phase-change contrast agentsR01AI167978 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Virginie Papadopoulou, Sarah Elizabeth Rowe · 2023 to 2026
$2.1M
Antibiotic treatment failure of Klebsiella pneumoniae liver abscessesR21AI187752 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROWE, SARAH ELIZABETH · 2025 to 2025
$428k
Elucidating the role of fimbriae in Klebsiella pneumoniae-mediated liver abscess formationR21AI190273 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROWE, SARAH ELIZABETH · 2025 to 2025
$428k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI167978HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI187752HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI190273NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI167978NIAID NIH HHS R21 AI187752NIAID NIH HHS R21 AI190273
6 · The paper itself

Abstract

Liver abscesses caused by hypervirulent

Indexed as

Anti-Bacterial AgentsKlebsiella InfectionsKlebsiella pneumoniaeLiver AbscessAnimalsDisease Models, AnimalDrug Resistance, BacterialLiverMiceMicrobial Sensitivity TestsAnti-Bacterial Agentsantibiotic tolerancedrug penetrationKlebsiella liver abscessestreatment failure

Identifiers

PMID41296732
PMCPMC12685145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.