Evidence map›Paper›PMID 41296716›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains.

Joseph P DeFranco, Jifeng Bian, Sehun Kim, Zoe N Atkinson, Jenna Crowell, Hae-Eun Kang, Hannah O Bodrogi, Jeffrey R Christiansen, Carlos M Díaz-Domínguez, Glenn C Telling

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joseph P DeFrancoPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0003-3194-2677
Jifeng BianPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0001-6838-9938
Sehun KimPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.
Zoe N AtkinsonPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0009-0009-8242-9305
Jenna CrowellPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0009-0009-9515-1023
Hae-Eun KangPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0002-6013-484X
Hannah O BodrogiPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.
Jeffrey R ChristiansenPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.
Carlos M Díaz-DomínguezPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0002-0410-1963
Glenn C TellingPrion Research Center, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0002-6294-1805

Funding

Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CLAUDIO SOTO · 2008 to 2026
$36.1M
Maximizing research success in studies of naturally-occurring prion diseasesR35NS132226 · NINDS · COLORADO STATE UNIVERSITY · PI Glenn C Telling · 2023 to 2026
$3.1M
Mechanisms of prion spread and establishment of infectionR01NS107246 · NINDS · CREIGHTON UNIVERSITY · PI BARTZ, JASON C, KINCAID, ANTHONY E. · 2018 to 2022
$2.4M
Characterizing the strain and host range properties of prions causing emergent forms of chronic wasting diseaseR01NS109376 · NINDS · COLORADO STATE UNIVERSITY · PI TELLING, GLENN C · 2018 to 2022
$2.4M
Addressing the mechanisms of prion strain evolution and its effect on interspecies transmissionR01NS121682 · NINDS · COLORADO STATE UNIVERSITY · PI TELLING, GLENN C · 2021 to 2023
$1.5M
Eusko Jaurlaritza (Gobierno Vasco) POS_2023_1_0013HHS | NIH (NIH) 1R01NS109376HHS | NIH (NIH) 1R01NS121682HHS | NIH (NIH) P01AI077774HHS | NIH (NIH) R01NS107246HHS | NIH (NIH) R35NS132226HHS | NIH (NIH) T32AI5310704NIAID NIH HHS P01 AI077774NINDS NIH HHS R01 NS107246NINDS NIH HHS R01 NS109376NINDS NIH HHS R01 NS121682NINDS NIH HHS R35 NS132226
6 · The paper itself

Abstract

Our previous demonstration that replacement of murine cellular prion protein (PrP

Indexed as

Host SpecificityPrionsPrPC ProteinsAnimalsDeerMiceSpecies SpecificityWasting Disease, ChronicPrionsPrPC Proteinschronic wasting diseaseinfectious host rangeneurodegenerative diseasesprionsstrains

Identifiers

PMID41296716
PMCPMC12685123

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.