Evidence map›Paper›PMID 41296665›Full record

ReviewHormone research in paediatrics2025

EndoCompass Project: Research Roadmap for Calcium and Bone Endocrinology.

Katharina Jähn-Rickert, Karin Zibar Tomšić, Athanasios D Anastasilakis, Jean-Philippe Bertocchio, Maria Luisa Brandi, Martin Fassnacht, Moira Shang-Mei Cheung, Evelien Gevers, Neil Gittoes, Outi Mäkitie and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Katharina Jähn-RickertDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, k.jaehn@uke.de.
Karin Zibar TomšićDepartment of Endocrinology and Diabetology, University Hospital Centre Zagreb, Zagreb, Croatia.
Athanasios D AnastasilakisDepartment of Endocrinology, 424 Military General Hospital, Thessaloniki, Greece.
Jean-Philippe BertocchioThyroid-Endocrine Tumors Department, Pitie-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Maria Luisa BrandiInstitute of Endocrine and Metabolic Sciences, Vita-Salute San Raffaele University and IRCCS, Milan, Italy.
Martin FassnachtDivision of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Wurzburg, Germany.
Moira Shang-Mei CheungDepartment of Paediatric Endocrinology, Great Ormond Street Hospital, London, UK.
Evelien GeversCentre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Neil GittoesCentre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK.
Outi MäkitieChildren's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Gabriel Ángel Martos-MorenoDepartments of Pediatrics and Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Madrid, Spain.
Petar MilovanovicCentre of Bone Biology, Institute of Anatomy, University of Belgrade, Faculty of Medicine, Belgrade, Serbia.
Adalbert RaimannDepartment of Paediatrics and Adolescent Medicine, Centre of Growth, Medical University of Vienna, Vienna, Austria.
Michaela TencerovaMolecular Physiology of Bone, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.
Elena TsourdiDepartment of Medicine III, Technische Universität Dresden, Dresden, Germany.
Annegreet G VlugCentre for Bone Quality, Department of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands.
Wolfgang HöglerCentre for Growth and Osteology, Department of Paediatrics and Adolescent Medicine, Johannes Kepler University Linz, Linz, Austria.
Peter KamenickýUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Service d'Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies du Métabolisme du Calcium et du Phosphate, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicetre, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology - aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

methodsResearch priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in bone and calcium endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

resultsResearch priorities encompass primary hyperparathyroidism, chronic hypoparathyroidism, and rare calcium-phosphate disorders. Key areas include bone as endocrine organ, bone mass acquisition, secondary osteoporosis, and skeletal dysplasias. Special emphasis is placed on cellular senescence, sex-specific differences in disease manifestation, and development of novel diagnostic tools for bone quality assessment.

conclusionsThis component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into metabolic bone disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.

Indexed as

Biomedical ResearchBone and BonesCalciumDatabases, FactualEndocrinologyChildFemaleHumansMaleCalciumBoneBone mass acquisitionBone mineralizationBone qualityCalciumCellular senescenceDiagnostic technologiesHypoparathyroidismHypophosphataemiaInactivating PTH/PTHrP signalling disordersOsteocytesOsteoporosisParathyroid hormonePhosphatePrimary hyperparathyroidismSkeletal dysplasiaTargeted treatmentsVitamin D

Identifiers

PMID41296665
PMCPMC12698132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.