ArticleJournal of cardiovascular medicine (Hagerstown, Md.)2025
Determinants of recovery from right ventricular dysfunction after transcatheter edge-to-edge tricuspid valve repair.
Article in Journal of cardiovascular medicine (Hagerstown, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTranscatheter edge-to-edge tricuspid valve repair (T-TEER) has emerged as a well tolerated and efficacious treatment modality among patients with tricuspid valve regurgitation. Right ventricular dysfunction (RVD) has been observed in up to 22% of patients undergoing T-TEER. Currently, the determinants of RVD recovery are not sufficiently understood.
methodsAll patients in four German tertiary cardiac centers scheduled for T-TEER were included for analysis. Patients were divided according to concomitant RVD at the time of T-TEER. RVD was defined as impairment of either tricuspid plane systolic excursion (TAPSE) or right ventricular fractional area change (RV-FAC). The primary endpoint of the study was recovery from RVD during follow-up 3 months after T-TEER. Predictors of RVD recovery were identified via univariable and multivariable logistic regression analyses.
resultsA total of 105 patients were included. Concomitant RVD was present in 43.8% of the patients (46/105). Recovery from RVD was observed in 47.8% (22/46) of patients, particularly in patients with mild RVD at baseline according to the TAPSE. A sufficient reduction in tricuspid valve regurgitation to mild severity likewise constituted a predictor of RVD recovery and emerged as a surrogate parameter of reduced right ventricular volume overload.
conclusionRecovery from RVD was most likely in patients who presented with mild RVD and a sufficient reduction in tricuspid valve regurgitation to mild severity according to T-TEER. Early identification and interventional treatment of today's patients with high-grade tricuspid valve regurgitation and RVD represent key factors in providing relief for this particular cohort of patients.
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