Evidence map›Paper›PMID 41296565›Full record

ArticleCell reports2025

Noradrenergic tuning of arousal is coupled to movement transitions.

Li Li, Akshay N Rana, Esther M Li, Bailey A Wells, Sayaka J Kenmochi, Myesa O Travis, Michael R Bruchas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Li LiDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Seattle Children's Research Institute, Seattle, WA 98101, USA. Electronic address: lili1@uw.edu.
Akshay N RanaDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Esther M LiDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Psychology, University of Washington, Seattle, WA 98105, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco CA 94158, USA.
Bailey A WellsDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA.
Sayaka J KenmochiDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA.
Myesa O TravisSeattle Children's Research Institute, Seattle, WA 98101, USA.
Michael R BruchasDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Rutgers New Jersey Medical School, Newark, NJ 07103, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: mbruchas@uw.edu.

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2019 to 2026
$13.0M
Decoding Locus Coeruleus Neural Circuits and Signaling In Negative AffectR01MH112355 · NIMH · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2016 to 2026
$5.3M
Unraveling the Locus Coeruleus Circuitry in Opioidinduced Sleep DisturbancesR00DA053336 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI LI, LI · 2023 to 2025
$747k
Unraveling the Locus Coeruleus Circuitry in Opioidinduced Sleep DisturbancesK99DA053336 · NIDA · UNIVERSITY OF WASHINGTON · PI LI, LI · 2021 to 2022
$350k
NIDA NIH HHS K99 DA053336NIDA NIH HHS P30 DA048736NIDA NIH HHS R00 DA053336NIMH NIH HHS R01 MH112355
6 · The paper itself

Abstract

Matching arousal state to an animal's behavioral demands is crucial for efficiently allocating cognitive and metabolic resources. Prior studies implicate cortical noradrenergic (NA) signaling in behavioral state changes, but whether this reflects a global signal and how it affects arousal remain unclear. Here, we examine the locus coeruleus (LC), the main source of cortical norepinephrine, in movement transitions and clarify its arousal-promoting potential during emergence from anesthesia. Using physiological recordings, fiber photometry, optogenetics, and behavioral tracking, we show that LC

Indexed as

ArousalLocus CoeruleusNorepinephrineAnimalsMaleMiceMice, Inbred C57BLMovementNorepinephrineanesthetic emergencearousalbehavioral arousalCP: neurosciencelocomotor movementlocus coeruleusnorepinephrinesympathetic arousal

Identifiers

PMID41296565
PMCPMC12721474

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.