ArticleNucleic acids research2026
enhancer3D: 3D chromatin structures and enhancer-promoter distance profiles for archaic and modern human genomes.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The 2026 Nucleic Acids Research database issue and the online molecular biology database collection.Nucleic acids research · 2026Article
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5 authors.
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Abstract
Spatial interactions between enhancers and promoters (E-P) are fundamental to gene regulation, yet understanding their evolution, particularly in the context of human divergence and uniqueness, remains a significant challenge. To address this, we present enhancer3D, which is, to our knowledge, the first publicly accessible database of 3D chromatin model ensembles for archaic (Neanderthal and Denisovan) and modern human genomes. The resource enables comparative analysis of E-P spatial distance profiles across evolutionary lineages and between different modern human cell lines (GM12878, HFFc6, and H1-ESC). This facilitates novel investigations into how structural variants and evolutionary divergence impact gene regulation by altering 3D chromatin conformation. For improved user usability, enhancer3D offers an intuitive web interface with integrated visualisation tools, including an embedded IGV genome browser for genomic context and an NGL viewer for interactive exploration of 3D models. All models and datasets are freely available at https://3dgnome.mini.pw.edu.pl/enhancer3D/.
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