ArticleAging2025
REVIVE: a computational platform for systematically identifying rejuvenating chemical and genetic perturbations.
Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Great efforts have been devoted to discovering rejuvenation strategies that counteract age-related functional decline and improve cellular functions in humans. However, new discoveries are currently driven by expert knowledge and require large amounts of resources. Here, we present REVIVE (Rejuvenation Estimation Via Insightful Virtual Experiments), the first computational framework for systematically predicting chemical and genetic perturbations that can restore a youthful transcriptional state based on gene expression data. REVIVE leverages age predictions to detect significant rejuvenating effects and quantifies the impact of perturbations on the hallmarks of aging. When applied to a large-scale
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Registered trials
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