Evidence map›Paper›PMID 41296493›Full record

ArticleJournal of neurogenetics2025

A cell-autonomous role for the vitamin B6 metabolism gene

Wenqin Fu, Saul Landaverde, Xiaoxi Zhuang, Atulya Iyengar

Abstract read
In one paragraph

Article in Journal of neurogenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wenqin FuDepartment of Neurobiology, University of Chicago, Chicago, IL, USA.
Saul LandaverdeDepartment of Biological Sciences, University of Alabama, Tuscaloosa, AL, USA.
Xiaoxi ZhuangDepartment of Neurobiology, University of Chicago, Chicago, IL, USA.
Atulya IyengarDepartment of Biological Sciences, University of Alabama, Tuscaloosa, AL, USA.

Funding

Drosophila and mouse models of PNPO deficiencyR01NS111122 · NINDS · UNIVERSITY OF CHICAGO · PI ZHUANG, XIAOXI · 2020 to 2024
$2.1M
Optimized Anti-Epileptic Screening Using Drosophila ModelsR61NS134960 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI REITER, LAWRENCE T · 2025 to 2025
$364k
NINDS NIH HHS R01 NS111122NINDS NIH HHS R61 NS134960
6 · The paper itself

Abstract

In animals, the enzyme pyridox(am)ine 5'-phosphate oxidase (PNPO) is critical for synthesizing the active form of vitamin B6 (VB6), pyridoxal 5'-phosphate (PLP), from inactive vitamers. PLP is a required cofactor for many enzymatic reactions, including the synthesis of GABA and the monoamines.

Indexed as

Drosophila ProteinsGABAergic NeuronsPyridoxaminephosphate OxidaseVitamin B 6AnimalsAnimals, Genetically ModifiedDrosophilaDrosophila melanogasterHumansSeizuresDrosophila ProteinsPyridoxaminephosphate OxidaseVitamin B 6Pyridoxalpyridoxal 5′-phosphate

Identifiers

PMID41296493
PMCPMC13366548

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.