Evidence map›Paper›PMID 41296465›Full record

ArticleCurrent issues in molecular biology2025

Stachydrine Ameliorates Uterine Hypercontractility in Primary Dysmenorrhea by Targeting the COX-2/PGF2α Pathway.

Yongfeng Cheng, Shuo Chen, Dianjie Cao, Hairu Cheng, Siyuan Chen, Yi Shu, Yue Wang, Zhiwu Chen

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongfeng ChengClinical College of Anhui Medical University, Hefei 230012, China.
Shuo ChenSchool of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230038, China.
Dianjie CaoClinical College of Anhui Medical University, Hefei 230012, China.
Hairu ChengClinical College of Anhui Medical University, Hefei 230012, China.
Siyuan ChenClinical College of Anhui Medical University, Hefei 230012, China.
Yi ShuClinical College of Anhui Medical University, Hefei 230012, China.
Yue WangSchool of Life Science, University of Science and Technology of China, Hefei 230027, China.
Zhiwu ChenDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.

Funding

China Association for Promotion of Health Science and Technology (No. JKHY2024011he Quality Engineering Project of the Anhui Provincial Department of Education No. 2022cyts017National Natural Science Foundation of China No. 81973510the Key Natural Science Research Projects of Anhui Universities Nos. KJ2019A0943, KJ2020A022, KJ2021A1227, and 2023AH040356
6 · The paper itself

Abstract

Primary dysmenorrhea (PDM) is a typical gynecologic disease in which uterine contractions and inflammation cause pain. Stachydrine (Sta) possesses multiple pharmacological activities but its effect on PDM has not yet been clarified. In vitro uterine contraction and oxytocin (OT)-induced PDM mouse models were used to evaluate the effect of Sta. Sta (10

Indexed as

COX-2IndoPDMPGF2αstachydrineuterine contractions

Identifiers

PMID41296465
PMCPMC12651120

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.