Evidence map›Paper›PMID 41296423›Full record

ArticleCurrent issues in molecular biology2025

Molecular and Serological Tests for SARS-CoV-2 Detection in Indeterminate Serology: Can We Skip the Second Sample?

Ivo N Sirakov, Kalina Shishkova, Stoyan Shishkov, Ivailo Alexiev

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ivo N SirakovDepartment of Medical Microbiology "Corr. Mem. Prof. Ivan Mitov, MD, DMSc", Faculty of Medicine, Medical University of Sofia, 2 "Zdrave" Str., 1431 Sofia, Bulgaria.ORCID 0000-0002-4765-3231
Kalina ShishkovaLaboratory of Virology, Faculty of Biology, University of Sofia "St. Kl. Ohridski", 1164 Sofia, Bulgaria.
Stoyan ShishkovLaboratory of Virology, Faculty of Biology, University of Sofia "St. Kl. Ohridski", 1164 Sofia, Bulgaria.ORCID 0000-0002-8203-3812
Ivailo AlexievNational Reference Laboratory of HIV, National Center of Infectious and Parasitic Diseases, 1233 Sofia, Bulgaria.ORCID 0000-0002-3186-1124

Funding

Medical University of Sofia, Bulgaria, Research Project 7927/19.11.2020"Scientific Research, Innovation, and Digitalization for Intelligent Transformation 2021-2027" BG16RFPR002-1.014-0017-C01
6 · The paper itself

Abstract

Indeterminate serological results for SARS-CoV-2 antibodies create diagnostic uncertainty, requiring repeat testing after 14-21 days to establish seroconversion. This study evaluated whether direct viral detection methods could provide immediate diagnostic information in serum samples with indeterminate antibody results. We analyzed 163 serum samples from clinically healthy individuals collected during March-December 2020 in Bulgaria. Samples were categorized by screening ELISA (IgA/M/G) as positive (

Indexed as

antigen detectiondiagnostic uncertaintyindeterminate serologyRT-PCRSARS-CoV-2

Identifiers

PMID41296423
PMCPMC12651152

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.