Evidence map›Paper›PMID 41296287›Full record

ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026

Effects of a Short-Term Nutritional Intervention on Vascular Changes in Individuals with Obesity and Low or Moderate Cardiovascular Health.

Michelle Rabello Cunha, Samanta Mattos, Mariana Ribeiro Costa Portugal, Elenilson Nobrega Gomes, Douglas Fernandes Souza, Wille Oigman, Márcia R S T Klein, Mario F Neves

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Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Michelle Rabello CunhaDepartment of Applied Nutrition, Nutrition Institute, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
Samanta MattosDepartment of Clinical Medicine, State University of Rio de Janeiro (UERJ), Ave. 28 de Setembro, 77 room 329, Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil.
Mariana Ribeiro Costa PortugalDepartment of Applied Nutrition, Nutrition Institute, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
Elenilson Nobrega GomesDepartment of Clinical Medicine, State University of Rio de Janeiro (UERJ), Ave. 28 de Setembro, 77 room 329, Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil.
Douglas Fernandes SouzaDepartment of Clinical Medicine, State University of Rio de Janeiro (UERJ), Ave. 28 de Setembro, 77 room 329, Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil.
Wille OigmanDepartment of Clinical Medicine, State University of Rio de Janeiro (UERJ), Ave. 28 de Setembro, 77 room 329, Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil.
Márcia R S T KleinDepartment of Applied Nutrition, Nutrition Institute, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
Mario F NevesDepartment of Clinical Medicine, State University of Rio de Janeiro (UERJ), Ave. 28 de Setembro, 77 room 329, Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil. mariofneves@gmail.com.ORCID http://orcid.org/0000-0002-0797-572X

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 313296/2021-9Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/200.473/2023
6 · The paper itself

Abstract

introductionMost cardiovascular events can be prevented by controlling health conditions and behaviors that reflect cardiovascular health (CVH) classification as high, moderate, and low.

aimTo evaluate the effect of weight loss through an 8-week hypocaloric diet on vascular function and sympathetic tone in individuals with obesity and moderate or poor CVH.

methodsIndividuals aged 40-70 years and body mass index  ≥ 30 kg/m

resultsSeventy-one patients were divided into moderate CVH (n = 44) and low CVH (n = 27) groups. After the intervention, both groups presented similar weight loss (3.4 vs 3.1%). Only the low CVH group showed a significant reduction in central systolic blood pressure (cSBP, 113 ± 12 to 109 ± 9 mmHg; p = 0.049) and an increase in cutaneous vascular conductance in post-occlusive reactive hyperemia (CVC-PORH, 0.99 ± 0.28 to 1.08 ± 0.28 APU/mmHg; p = 0.039). Conversely, only the moderate CVH group exhibited an increase in RR interval (933 ± 130 to 994 ± 131 ms; p = 0.006) and a decrease in sympathetic nervous system index (iSNS). Significant inverse correlations were observed in the low CVH group between the variations in CVC-PORH with pulse wave velocity (r = - 0.40, p = 0.044) and with iSNS (r = - 0.52, p = 0.021).

conclusionEven modest weight loss led to early improvements in vascular function and blood pressure in individuals with low CVH, while autonomic benefits were more evident in those with moderate CVH.

Indexed as

Caloric RestrictionCardiovascular DiseasesHemodynamicsNutritional StatusObesitySympathetic Nervous SystemWeight LossAdultAgedBlood PressureFemaleHeart RateHumansMaleMicrocirculationMiddle AgedArterial stiffnessCardiovascular healthEndothelial dysfunctionHeart rate variabilityObesityWeight loss

Identifiers

PMID41296287

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.