ReviewMolecular and cellular biochemistry2026
Klotho in aging and diseases: molecular features, expressions, and functional implications.
Review in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical exercise and circulating α-Klotho in humans: a systematic review and meta-analysis with emphasis on older adults.Frontiers in sports and active living · 2026Pooled it
- Hyperbranched poly(β-amino ester)s-mediated delivery of engineered Klotho mRNA rescues senescence and restores cellular homeostasis in aged and Klotho deficient iMSCs.Drug delivery and translational research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The protein Klotho, recognized for its anti-aging properties, has emerged as a significant focus in gerontological research due to its capacity to extend lifespan and confer protection against numerous age-associated pathologies. Genetic ablation of the Klotho gene frequently precipitates accelerated aging phenotypes and systemic organ deterioration, functionally recapitulating the multi-organ decline observed in physiological aging. A substantial body of evidence substantiates the salutary effects of Klotho on various age-related tissue and organ insults. This review aims to delineate the multifaceted roles of Klotho in the aging process, emphasizing its intricate interactions with diverse metabolic pathways crucial for maintaining systemic homeostatic equilibrium. We underline how diminished Klotho levels, frequently observed in aged cohorts, contributing to the uncontrolled progression of age-associated diseases. Additionally, this review highlights the burgeoning therapeutic potential of Klotho protein as a viable intervention for ameliorating age-related conditions. Ultimately, this comprehensive review provides a nuanced understanding of Klotho biology, elucidating the molecular mechanisms by which it contributes to homeostatic regulation and confers protection against senescence-associated morbidities.
Indexed as
Identifiers
41296273What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.