ArticleOncology and therapy2026
Exploratory Analyses of Patient Preferences for Atezolizumab Subcutaneous Versus Intravenous from the IMscin002 Study in Patients with Non-Small Cell Lung Cancer.
Article in Oncology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05171777 (A Randomized, Multicenter, Open-Label Cross-Over Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab Compared With Intravenous Atezolizumab Formulation in Participants With Non-Small Cell Lung Cancer), which is not on this map. Not yet cited in PubMed.
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A Randomized, Multicenter, Open-Label Cross-Over Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab Compared With Intravenous Atezolizumab Formulation in Participants With Non-Small Cell Lung Cancer
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12 authors.
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Abstract
introductionThe primary analysis of IMscin002 (NCT05171777) demonstrated that most patients preferred atezolizumab subcutaneous (SC) administration over intravenous (IV) administration; we report patient preference according to baseline characteristics, mean injection duration, and cumulative number of SC injections at each center from IMscin002.
methodsIn this phase 2, randomized, open-label, crossover trial, patients aged ≥18 years, with EGFR/ALK wild-type tumors and either PD-L1+ (≥ 1%) resected non-small cell lung cancer (NSCLC) (stage 2, 3a, or selected 3b; AJCC 8th edition) with prior chemotherapy and no evidence of recurrence, or untreated PD-L1-high (≥ 50%) stage 4 NSCLC were eligible. Patients, randomized 1:1, received atezolizumab IV or SC for three cycles before switching to the alternative formulation for another three cycles. Patients chose a formulation for the continuation period after cycle 6. PRIMARY ENDPOINT: patient preference for atezolizumab SC/IV.
resultsAmong 179 patients randomized, demographics and characteristics were generally balanced between arms. Overall, 87/123 patients (70.7%) preferred atezolizumab SC, of whom 86.2% had a very/fairly strong preference compared with 69.2% of patients who preferred IV (n = 26/123, 21.1%). Patient preference for atezolizumab SC was independent of baseline characteristics and mean injection duration. A higher proportion of preference was seen in patients aged > 74 years (87.5%). A trend for a greater number of patients preferring atezolizumab SC over IV was seen in patients at centers where a higher number of cumulative injections (> 47 to ≤ 164) were administered before preference disclosure.
conclusionsMost patients preferred atezolizumab SC regardless of baseline characteristics, mean injection duration, and cumulative number of SC injections. The trend for a stronger preference was higher among patients who preferred SC than those who preferred IV. Our findings suggest that the proportion of preference for atezolizumab SC over IV is highest in patients aged > 74 years, and that administrator's experience could be an important factor influencing patient preference. CLINICAL TRIAL REGISTRATION NUMBER: NCT05171777.
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