ArticleAging clinical and experimental research2025
The association between body fat distribution and osteosarcopenia in older adults: evidence from the PoCOsteo study.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Prevalence, risk factors and adverse health outcomes of osteosarcopenia in middle-aged and older adults with type 2 diabetes mellitus-a scoping review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
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8 authors.
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Abstract
backgroundOsteosarcopenia is a syndrome associated with aging, characterized by the simultaneous occurrence of two conditions: osteopenia and sarcopenia. The association between various fat mass distributions across the body and osteosarcopenia is not clear.
methodsCross-sectional data from the PoCOsteo study, involving 1,897 participants, were used. T-score was used to define osteopenia. Sarcopenia was identified based on the skeletal muscle mass index (SMI), handgrip strength measurements, and/or a walking speed. Body fat distribution was assessed using Dual X-ray absorptiometry.
resultsRegression models, after adjustment for covariates-age, gender, marital status, tobacco use, income, education, occupation, and hypertension-revealed a negative association between various fat deposits-including total, gynoid, trunk, arm, and android fat-as well as indices of body mass index (BMI) and the trunk-to-limb fat mass ratio, with both osteoporosis and sarcopenia. A significant inverse relationship was also observed between osteosarcopenia and total fat (OR = 0.946, 95% CI: 0.918-0.975), android fat (OR = 0.932, 95% CI: 0.911-0.953), trunk fat (OR = 0.927, 95% CI: 0.903-0.952), and BMI (OR = 0.738, 95% CI: 0.703-0.775).
conclusionOsteosarcopenia and its components (osteoporosis and sarcopenia) are inversely associated with BMI and fat mass, particularly in the trunk and android regions.
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