ArticleMolecular biology reports2025
Extracellular vesicles derived from dental mesenchymal stem cells for regenerative medicine: a scoping review.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular vesicles (EVs), particularly small EVs (sEVs), are nanoscale particles secreted by cells that mediate intercellular communication and hold promise in tissue regeneration. Dental mesenchymal stem cells (D-MSCs) are an attractive source of sEVs due to their non-invasive collection, ease of expansion, and low immunogenicity. This scoping review aimed to evaluate current evidence on the regenerative potential of sEVs derived from D-MSCs (D-MSC-sEVs) and the methods used for their isolation and application. A search was performed using PubMed/MEDLINE, Scopus, Web of Science, and EMBASE. The inclusion criteria were studies investigating D-MSC-sEVs in all languages and data. Studies not using human MSCs or in vitro models were excluded. The search resulted in 2,285 records and 44 studies were included. D-MSC-sEVs were obtained from the dental pulp of permanent and deciduous teeth, periodontal ligament, apical papilla, dental follicle, and gingiva. The most robust evidence of D-MSC-sEVs has been from craniofacial tissues, with particular emphasis on increasing bone volume and the number of trabeculae in defects, with improved angiogenesis and neurogenesis. They have also been investigated for skin, nervous tissues, joints, tendons, angiogenesis, and inflammation. These results demonstrate the potential of using D-MSC-sEVs for immunomodulation and regeneration for different diseases as an alternative to cellular therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.